多个时间点的血液维生素D水平和5岁儿童喘风险
Chisato Hara1, Ryohei Shibata2, Taiji Nakano3
1Department of Nutrition and Metabolic Medicine, Center for Preventive Medical Science, Graduate School of Medical and Pharmaceutical Sciences, Chiba University, Chiba, Japan.
概括
胎儿维生素D水平,测量在带血中,显示最强的链接到儿童喘风险. 这表明产前维生素D暴露对于预防喘发展至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 环境健康 环境健康
背景情况:
- 维生素D在免疫系统发育中起作用.
- 维生素D对儿童喘的影响尚未完全理解.
- 之前对维生素D和儿童喘的研究已经产生了不一致的结果.
研究的目的:
- 调查怀孕和幼儿时期维生素D状况与儿童喘风险之间的联系.
- 为了确定与喘发展有关的维生素D暴露的关键发育窗口.
主要方法:
- 在205名儿童的血清中测量了25-氧维生素D (25(OH) D) 水平,分别在5个时间点进行测量:母体血液 (妊娠36周),带血液和1,2,5岁儿童血液.
- 喘诊断是根据国家指南在5岁时进行的.
- 使用了多项逻辑回归模型,对母亲喘,产前吸烟和出生季节进行了调整.
主要成果:
- 孕产妇和带血25 ((OH) D水平较低 (平均值分别为12.0 ng/mL和6.0 ng/mL).
- 产后25(OH) D水平在21.0~23.4 ng/mL之间.
- 带血25(OH) D显示在5岁时与喘风险的边际反向关联 (aOR 0.801每1 ng/mL).
结论:
- 带血25(OH) D水平在5岁时显示出与喘风险的最强相关性.
- 胎儿维生素D暴露似乎是喘发展的关键窗口.
- 孕产妇和产后维生素D水平与喘风险的关联较弱.
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