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皮质醇调节PD-1和IL-12在狗的莱什曼病

Lucas Takeshi Siqueira Ito¹, Gisele Mitsue Umino¹, Mayla Abbas Guimarães¹

¹Department of Clinical Medicine, Surgery and Animal Reproduction, São Paulo State University (UNESP), Araçatuba, Brazil.

Parasite immunology

|February 2, 2026

概括

狗的内脏莱什曼病 (CanL) 与下丘脑-垂体-上腺 (HPA) 轴障碍有关,显示皮质醇增加和免疫反应改变. 这项研究揭示了受感染狗的皮质醇和特定免疫标记的升高,有助于了解疾病.

科学领域:

兽医免疫学兽医免疫学
寄生虫学的寄生虫学
内分泌学在内分泌学.

背景情况:

由于Leishmania infantum引起的狗内脏莱什曼病 (CanL) 是一种热带动物病.
在人类的莱什曼病中已知下丘脑-垂体-上腺 (HPA) 轴的失调,但在狗中没有得到广泛的研究.
皮质醇在调节免疫反应中起着关键作用.

研究的目的:

为了研究与CanL.L.狗的HPA轴障碍.
将这些疾病与临床和免疫学参数相关联.
了解犬类Leishmania婴儿感染的致病机制.

主要方法:

使用ELISA量化血清皮质醇和上腺皮质增生激素 (ACTH).
在外围血液单核细胞 (PBMC) 中通过流细胞计评估可诱导的氧化合成酶 (iNOS),酶-1和编程细胞死亡蛋白-1 (PD-1) 的表达.
测量了血清细胞因子水平 (IL-1β,IL-6,IL-10,IL-12,IFN-γ,TNF-α,TGF-β) 和寄生虫负荷 (qPCR).

主要成果:

患有CanL的狗表现出血清皮质醇增加和ACTH水平降低.
在感染狗的PBMC中观察到 iNOS,阿尔金酶-1和PD-1的更高表达.
在患有CanL.L.的狗中检测到IL-10,IL-6,IL-12和IFN-γ的血清水平升高. 皮质醇与PD-1和IL-12负相关.

结论:

狗的天然Leishmania婴儿感染可以诱导HPA轴的失调.
皮质醇水平升高与调节的免疫反应和CanL病变发生中的特定免疫标记物有关.
这些发现有助于更好地了解CanL在狗中的致病机制.

关键词:

这些狗狗狗狗狗狗狗狗.葡萄糖皮质类药物是什么荷尔蒙障碍荷尔蒙障碍荷尔蒙障碍有关内脏的莱什曼病.

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