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Updated: Feb 4, 2026

Author Spotlight: Detecting Low-Abundant Host Cell Proteins in Drug Products Using Enrichment Beads and Limited Digestion
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Author Spotlight: Detecting Low-Abundant Host Cell Proteins in Drug Products Using Enrichment Beads and Limited Digestion

Published on: January 19, 2024

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定量分析揭示了搭便车驱动的多酸盐酶持久性通过宿主细胞蛋白质-抗体相互作用

Melanie Maier1,2, Lukas Griesinger1,2, Matthias Franzreb2

  • 1Drug Substance Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co.KG, Biberach an der Riss, Germany.

Biotechnology and bioengineering
|February 2, 2026
PubMed
概括

聚酸盐降解宿主细胞蛋白 (HCP) 和单克隆抗体 (mAbs) 之间的暂时相互作用可以在生物制造过程中导致HCP转移. 这项研究量化了这些相互作用,揭示了它们对下游处理中的HCP持久性有所贡献.

关键词:
生物层干涉度测试是生物层干涉度测试.下游加工是下游加工.车旅行 车旅行宿主细胞蛋白质 (HCPs) 的使用.一个单克隆抗体.聚酸盐降解降解的方法

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