肺部暴露后元素和物质的毒性;以及环境和职业空气中的度:一项审查
Niels Hadrup1,2, Morten Poulsen2, Gitte Ravn-Haren2
1The National Research Centre for the Working Environment, København, Denmark.
Drug and chemical toxicology
|February 2, 2026
概括
职业和环境暴露通过空气发生. 吸入的毒性数据有限,动物研究表明化在低至1mgSe/m3的度时会产生不良影响.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 职业健康 职业健康 职业健康
背景情况:
- 通过吸入的方式暴露于是环境和职业环境中都令人担忧的.
- 了解不同形式的的毒性对于保护人类至关重要.
研究的目的:
- 审查环境和职业空气的度.
- 在肺部暴露后评估的生物动力学和毒性.
主要方法:
- 对环境/职业气度的文献综述.
- 对生物动力学和吸入暴露后毒性的文献综述.
- 对各种化合物的吸入和内灌注的动物研究的分析.
主要成果:
- 环境含量范围从0.1到20 ng/m3,而职业含量可以达到2 mg/m3.
- 吸入的分发到血液和器官,通过尿液,便和呼吸排泄.
- 动物研究表明,最低观察到的不良影响度 (LOAECs) 为1 mg Se/m3 (二) 和33 mg Se/m3 (元素),最低观察到的不良影响水平 (LOAELs) 从0.06 mg Se/kg体重开始,用于内灌注.
结论:
- 职业水平可能远高于环境水平.
- 肺部暴露导致在体内分布.
- 来自动物研究的现有毒性数据强调了特定的空气中度和剂量的潜在风险.
关键词:
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