患有Helicobacter pylori感染的儿科患者的血管内皮质功能及其对Helicobacter pylori根除的反应
Ebtehal Abdelhai1, Doaa El Amrousy1, Naglaa Abou Taira2
1Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
Journal of pediatric gastroenterology and nutrition
|February 2, 2026
概括
在儿童中,Helicobacter pylori感染会导致内皮功能障碍和脂质失调. 根除疗法显著改善了这些标记物,表明儿科患者的H. pylori和心血管健康之间存在联系.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 心血管健康 心血管健康
- 传染性疾病 传染性疾病
背景情况:
- 杆菌 (H. pylori) 感染在儿童中很常见.
- 内皮功能障碍和脂质障碍是心血管疾病的危险因素.
- 对于H. pylori对儿童内皮细胞功能的影响尚不清楚.
研究的目的:
- 用流媒扩张 (FMD) 来评估感染H. pylori的儿童的内皮功能.
- 评估H. pylori根除治疗对内皮细胞功能和脂质样本的影响.
- 研究H. pylori感染,内皮功能障碍和心血管风险因素之间的关系.
主要方法:
- 60名有症状的儿童被分为H.pylori阳性 (n=30),H.pylori阴性 (n=30) 和健康的对照组 (n=30).
- 血液测试包括完整血清,hs-CRP和脂质资料.
- 脑内皮功能通过手臂动脉口腔疾病 (FMD) 来测量. 阳性H. pylori患者接受了2周的三重疗法,并在3个月后重新评估.
主要成果:
- 与H. pylori阳性和对照组 (p<0.001) 相比,H. pylori阳性儿童的hs-CRP,胆固醇,甘油三和LDL显著更高,血红蛋白,高血糖和口腔炎较低 (p<0.001).
- 在根除疗法后,响应者显示血红蛋白,高密度胆固醇和口疾病的显著增加.
- 成功根除导致hs-CRP和脂质配置文件显著下降 (p<0.001). FMD与症状持续时间,hs-CRP,胆固醇和悉尼分数负相关,与HDL积极相关.
结论:
- 患有H. pylori感染的儿童表现出内皮功能障碍和脂质失调症.
- 成功的H. pylori根除疗法显著改善了儿童的内皮功能和脂质概况.
- 皮洛里菌感染是儿科患者内皮功能障碍和脂质不良症的可修改风险因素.
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