在两个艾滋病毒感染者的队列中,自抗体中和1型干扰素
Julie A Jensen1,2,3, Nanna Mørk1,2,3, Martin Tolstrup2,4
1Department of Biomedicine, Aarhus University, Aarhus, Denmark.
概括
具有艾滋病毒的人群中存在自抗体中和I型干扰素 (IFN-I),其比例与一般人群相似. 这些自身抗体可能会增加对某些病毒感染的易感性,如疹病毒和HPV.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 传染性疾病 传染性疾病
背景情况:
- 自动抗体 (autoAbs) 中和I型干扰素 (IFN-I) 与严重的病毒性疾病表现有关.
- 在一般人群中,IFN-I自动Abs的患病率随着年龄的增长而增加,在65岁时达到约1%.
研究的目的:
- 确定IFN-I中和自动Abs在感染人类免疫缺陷病毒 (HIV) 的人群中的流行率.
- 调查IFN-I自动Abs,艾滋病毒感染和干扰素治疗史或其他病毒感染之间的潜在关联.
主要方法:
- 来自丹麦和美国艾滋病毒感染者 (接受ART治疗和未接受ART治疗) 的血清样本的分析.
- 使用特定测试检测中和IFN-ω,IFN-α2和IFN-β的自动Abs.
- 对IFN治疗,C型肝炎病毒 (HCV) 和其他病毒感染的相关病史的审查.
主要成果:
- 在联合的丹麦和美国艾滋病毒队列中,IFN-ω自动Abs的患病率为0.82% (5/610).
- 艾滋病毒感染者的IFN-I中和自动Abs的患病率与一般人群没有显著差异.
- 两名患有IFN-I自动Abs的人有IFN-α治疗HCV的病史;其他人有粘膜皮肤疹病毒,疹病毒和人类乳头瘤病毒 (HPV) 感染的病史.
结论:
- 与一般人群相比,IFN-I中和自动Abs在艾滋病毒感染者中并不比一般人群更为普遍.
- 型肝炎和干扰素治疗可能有助于IFN-I自身衰减的发展.
- IFN-I自动Abs可能会使个体易患粘膜皮肤性疹病毒感染和与HPV相关的瘤.
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