肠道微生物组成,功能和组装中的性别差异在高原zokor (Eospalax baileyi) 中
Lei Si1,2, Rui Zhang2, Jialong Guo3
1State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, Qinghai Province, China.
PeerJ
|February 2, 2026
概括
性别显著塑造高原zokor的肠道微生物群,影响微生物的结构和功能. 这些发现揭示了这种独特物种肠道细菌组装过程中的性别特异.
科学领域:
- 微生物学 微生物学
- 动物生态动物生态学
- 进化生物学 进化生物学
背景情况:
- 肠道微生物群对宿主健康至关重要,影响新陈代谢,免疫力和恒温.
- 性对高原 (Eospalax baileyi) 的肠道微生物群的影响尚不清楚.
- 这项研究调查了高原zokors的肠道微生物社区的基于性别的变异.
研究的目的:
- 探索性如何影响肠道微生物群的组成,功能和组装.
- 为了确定细菌多样性和社区结构的性别相关差异.
- 了解塑造性别特异性肠道微生物组的功能影响和生态过程.
主要方法:
- 16S rRNA基因测序 (V3-V4区域) 用于15个高原或胃肠道样本.
- 生物信息分析评估了细菌多样性,社区结构和功能预测 (PICRUSt).
- 生态建模 (中立社区模型,iCAMP) 研究了微生物社区组装过程.
主要成果:
- 肠道微生物社区结构在两性之间存在显著差异,尽管有相似的物种丰富性和多样性.
- 男性和女性共享占主导地位的细菌类 (Firmicutes,Desulfobacterota,Bacteroidota),但在相对丰度上有所不同.
- 男人显示较高的碳水化合物代谢,女性更高的异生物生物降解;分散限制和漂移是关键的组装过程,有性别特异的变化.
结论:
- 性是驱动肠道微生物结构,功能和装配的重要因素.
- 这些发现为高原科在具有挑战性的环境中的适应性进化提供了新的见解.
- 了解特定性别的肠道微生物组对于理解宿主微生物相互作用和适应至关重要.
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