为数字神经重建进行处理的神经全移植:系统性审查和聚合结果分析
Anil Regmi1, Surakshya Baral2, Abdus Sami3
1Department of Orthopaedics, Charak Memorial Hospital, Pokhara, Nepal.
Journal of hand and microsurgery
|February 2, 2026
概括
经过处理的神经全移植 (PNA) 在数字神经重建方面显示出有前途的结果,在低并发症率下提供显著的感官改善. 这次审查强调了PNA作为一个可行的替代品,当初级修复是不可行的.
科学领域:
- 再生医学是一种再生医学.
- 神经外科 神经外科
- 整形外科 整形外科 整形外科
背景情况:
- 数字神经受伤导致显著的感官损失,这给重建带来了挑战.
- 经过处理的神经全移植 (PNA) 为神经修复提供了一个无病症的生物支架.
- 在数字神经重建中PNA的证据有限,报告结果变化不定.
研究的目的:
- 系统地审查和汇集使用PNA的数字神经重建的感觉和功能结果的数据.
- 评估PNA在数字神经间隙重建中的有效性和安全性.
主要方法:
- 在PubMed,Embase和Scopus系统搜索相关研究.
- 包括报告定量感官结果的研究 (s2PD,m2PD,有意义的感官恢复).
- 采用随机效应模型对连续和比例结果进行聚合分析.
主要成果:
- 16项研究 (664名患者,886名全移植) 显示了持续的感官改善.
- 聚合的静态两点歧视 (s2PD) 平均为7-8毫米;移动的两点歧视 (m2PD) 平均为5-6毫米.
- 超过80%的人实现了有意义的感官恢复,并发症和感染率较低.
结论:
- PNA提供了有利的感官恢复,是当初级修复是不可能的数字神经重建的有效替代品.
- 报告的并发症率很低,没有与移植相关的重大不良事件.
- 需要进一步标准化结果测量和前性研究,以优化患者选择和康复预测指标.
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