肠道微生物多样性影响严重急性营养不良儿童的碳水化合物发酵
Akshay Bisht1, Jennifer Ahn-Jarvis1, Kendall Corbin2
1Food, Microbiome and Health, Quadram Institute Bioscience, Norwich, UK.
iScience
|February 2, 2026
概括
严重急性营养不良 (SAM) 的非洲儿童有肠道问题. 替代碳水化合物,而不是胰岛素,在肠道模型中有效地产生有益的短链脂肪酸 (SCFA),有助于恢复.
科学领域:
- 微生物学 微生物学
- 营养科学 营养科学
- 儿科 儿科 儿科
背景情况:
- 非洲儿童严重急性营养不良 (SAM) 与肠道微生物群的破坏和低短链脂肪酸 (SCFA) 有关.
- 这些肠道功能障碍导致SAM的高死亡率和发病率.
- 用可发酵碳水化合物补充饮食可能会改善治疗结果.
研究的目的:
- 研究SAM儿童肠道微生物群对不同碳水化合物基质的体外发酵.
- 评估各种碳水化合物恢复SCFA生产和支持肠道恢复的潜力.
主要方法:
- 利用SAM儿童的肠道微生物群的体外结肠模型.
- 发酵的四种碳水化合物基质:奶粉 (含/不含母乳寡糖),豆丰富料和胰岛素.
- 在发酵后分析了SCFA生产和微生物组成.
主要成果:
- 牛奶粉和小豆料有效地产生了SCFA,与胰岛素不同.
- 无法发酵胰岛素与低微生物多样性和蛋白质细菌丰富有关.
- 部分恢复显示微生物多样性增加和GH32酶活性增加,表明改善了胰岛素代谢潜力.
结论:
- 在SAM儿童的初始治疗阶段,肠道微生物群无法充分利用胰岛素.
- 替代碳水化合物,如乳制品和小豆料,在促进SCFA生产和肠道恢复方面更有效.
- 这些发现可以指导SAM改善的治疗饮食的开发,考虑到碳水化合物利用能力.
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