一种抗氧化和抗菌的八甲酸持续释放药膏用于牙周炎治疗
Han-Ping Wang1,2, Chen-Yu Xu1,2, Wen Su1,2
1Department of Orthodontics, Tianjin Medical University School and Hospital of Stomatology & Tianjin Key Laboratory of Oral Soft and Hard Tissues Restoration and Regeneration, No.12 Qixiangtai Road, Heping District, Tianjin 300070, P.R. China.
iScience
|February 2, 2026
概括
一种新型的基酸膏 (OG-膏) 为牙周炎治疗提供了一种有前途的非抗生素方法. 这种持续释放的配方有效地对抗细菌和炎症,减少动物模型中的骨损失.
科学领域:
- 牙周病学 牙周病学
- 药物运输 药物运输 药物运输
- 生物材料是一种生物材料.
背景情况:
- 牙周炎是导致牙脱落的主要原因,目前的治疗方法面临着深处的局限性和抗生素耐药性的风险.
- 氧基甲酸 (OG) 是一种天然化合物,具有抗菌和抗氧化特性,但溶解性和稳定性不佳.
- 开发有效的天然化合物输送系统对于治疗牙周炎等慢性炎症性疾病至关重要.
研究的目的:
- 开发和评估一种持续释放的药膏 (OG-药膏),用于增强酸乙 (OG) 的输送.
- 为了研究OG-Ointment的抗氧化和抗菌功效,无论是*in vitro*还是*in vivo*.
- 评估OG-Ointment作为一种潜在的牙周炎非抗生素辅助疗法.
主要方法:
- 使用Pluronic F127和乙烯基纤维素制备OG-膏,评估风湿性质和药物释放动力学.
- 在体外评估OG-Ointment的抗氧化活性 (ABTS+激素清除) 和对*P. gingivalis*和巨反应性氧物种 (ROS) 的影响.
- 在老鼠牙周炎模型中对OG-Ointment的体内评估,评估膜骨再吸收,ROS,炎症性细胞因子和生物相容性.
主要成果:
- 机基膏表现出有利的风湿学,持续的机基释放,以及强大的抗氧化能力.
- 实验室研究表明,增强了细菌膜的透性,抑制了P. gingivalis,并减少了巨细胞中的ROS.
- 鼠标模型显示,膜骨损失,ROS和炎症标志物显著减少,具有良好的生物相容性.
结论:
- OG-Ointment提供有效的持续释放氧基甲酸,显示出显著的抗氧化和抗菌特性.
- 该配方显示出作为 parodontitis 的非抗生素辅助疗法的承诺,减轻关键的病理特征.
- 对OG-Ointment的进一步研究可能会导致改善牙周炎的治疗策略,解决当前治疗方法的局限性.
关键词:
分子生物学分子生物学相关概念视频
Sustainable Development
15.1K
As the human population continues to grow and use resources, we must be mindful of our planet’s natural limits. Sustainable development provides a pathway to maintain and improve human life now while also ensuring that future generations will have the resources that they need. The long-term success of sustainability efforts rests on understanding the interplay between human actions and ecological systems.
15.1K
Design Example: Sustainability in Concrete Building
417
As the construction industry moves towards more eco-friendly practices, concrete's adaptability and its ability to incorporate sustainable features make it a key material in the drive towards greener building solutions.
There are multiple approaches to achieve sustainability in a commercial concrete building. For instance, construct a concrete parking area under the building, utilizing pervious concrete paver blocks in open areas to facilitate rainwater collection through an underground...
There are multiple approaches to achieve sustainability in a commercial concrete building. For instance, construct a concrete parking area under the building, utilizing pervious concrete paver blocks in open areas to facilitate rainwater collection through an underground...
417
Energy-releasing Steps of Glycolysis
146.8K
Glycolysis is divided into two phases based on whether energy is utilized or released. While the first phase consumes ATP, the second phase produces energy in the form of ATP and NADH. The energy is released over a sequence of reactions that turns G3P into pyruvate. The energy-releasing phase—steps 6-10 of glycolysis—occurs twice, once for each of the two 3-carbon sugars produced during steps 1-5 of the first phase.
The first energy-releasing step—the 6th step of glycolysis...
The first energy-releasing step—the 6th step of glycolysis...
146.8K
ATP Energy Storage and Release
14.4K
ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
One example of energy coupling using ATP involves a...
One example of energy coupling using ATP involves a...
14.4K
Drugs Affecting Neurotransmitter Release or Uptake
1.6K
Certain drugs can affect how neurotransmitters called catecholamines, are released or taken back up in the adrenergic neuron. They can have different effects on the body's sympathetic transmission. Reserpine, a natural compound found in the Rauwolfia shrub, blocks a transporter called vesicular monoamine transporter (VMAT), which leads to a buildup of catecholamines in the cell and reduces sympathetic transmission. Another drug called guanethidine works in multiple ways, including blocking...
1.6K
Open Angle Glaucoma: Treatment
997
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
997


