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Updated: Feb 4, 2026

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
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拼接的药理学干扰引起SMG1的减少:对癌症治疗的影响

Martin Barainka1, Angelina Zheleva1, Angela Pérez-Cervera1

  • 1Therapeutic Innovation Program, Center for Applied Medical Research, University of Navarra, Pamplona, Spain.

iScience
|February 2, 2026
PubMed
概括

拼接调节剂通过抑制无意中介mRNA衰变 (NMD) 来增强瘤免疫性,稳定促进癌症的转录. 这种双重作用促进了新抗原的产生,并选择性地准了依赖NMD的瘤.

关键词:
动物生物技术动物生物技术癌症 癌症 癌症 癌症 癌症免疫学 免疫学 免疫学

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