对于怀孕期间的热量 - 印度 (HiP-India) 研究的队列概况
Ramachandran Thiruvengadam1,2, Sreevatsan Raghavan1, Rekha Shanmugam3
1Translational Health Science and Technology Institute, Faridabad, Haryana, 121001, India.
Wellcome open research
|February 2, 2026
概括
这项研究调查了极端高温如何影响印度的怀孕结果,旨在确定脆弱性的生理标志物. 调查结果将为保护孕妇免受与热有关的风险的策略提供信息.
科学领域:
- 环境健康 环境健康
- 生殖流行病学 生殖流行病学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 暴露于极端的热量与不良的妊娠结果,如早产和死产有关.
- 怀孕期间热敏感性的机制和生物标志物尚不清楚.
- 怀孕中的热量-印度 (HiP-印度) 联盟旨在解决这些知识差距.
研究的目的:
- 描述母亲,胎盘和胎儿对热量,湿度和空气污染的生理反应.
- 确定怀孕期间与热有关的危险的关键窗口和机制.
- 发现生物标志物,表明个体对极端高温的脆弱性.
主要方法:
- 印度三个不同的气候区600名孕妇的前性队列研究.
- 暴露评估包括环境监测 (热量,湿度,空气污染) 和感知热应激问卷.
- 生理学和病理学评估包括母亲的血液动力学,核心体温,心率,血压,尿液特异重量,胎儿超声波,胎盘血流和母亲的血液生物标志物.
主要成果:
- 目前正在收集有关环境暴露,生理反应和怀孕结果的数据.
- 分析的重点是确定暴露在热量水平和母亲/胎儿生理变化之间的关联.
- 将评估胎盘功能,压力和哺乳生理学的生物标志物.
结论:
- 这项研究协议为了解印度多样化的气候中热量对怀孕的影响提供了一个框架.
- 预计这些发现将为全球孕妇的气候适应战略和公共卫生政策提供信息.
- 传播包括期刊出版物,参与者沟通和会议演讲.
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