局部复发性直肠癌对新辅助化疗或放射治疗的病理反应
Yuichiro Yokoyama1, Kosuke Ozaki1, Hiroaki Nozawa1
1Department of Surgical Oncology, University of Tokyo, Tokyo, Japan.
Journal of the anus, rectum and colon
|February 2, 2026
概括
局部复发性直肠癌 (LRRC) 显示对新辅助化学放射治疗 (CRT) 诱导的亡的耐药性. 这种不良的亡反应与高的复发率相关,需要新的术后策略来改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 癌症研究 癌症研究
- 结直肠癌的治疗方法
背景情况:
- 局部复发性直肠癌 (LRRC) 是一个重大的临床挑战.
- 新辅助化学辐射疗法 (CRT) 是一种标准治疗方法,但其在诱导LRRC中亡的疗效尚未完全理解.
- 了解亡反应对于优化治疗策略至关重要.
研究的目的:
- 为了评估LRRC对新辅助CRT使用M30 CytoDeath免疫染的亡反应.
- 研究LRRC患者的亡,瘤回归度 (TRG),瘤大小减少和长期结果之间的关联.
- 确定潜在的治疗目标,以改善LRRC治疗结果.
主要方法:
- 对9名LRRC患者的回顾性分析,这些患者接受了CRT和彻底手术.
- 使用M30 CytoDeath免疫染与评分系统 (0-3) 评估亡.
- 评估TRG,瘤大小减小,R0切除率和生存数据.
主要成果:
- 没有观察到病理完整反应;大多数患者有TRG 1.
- M30 细胞死亡染色显示主导得分为0,表明亡低;没有病例得分≥2.2.
- 瘤大小的减少是常见的,R0切除率为77.8%.
- 在R0切除中,5年局部无复发存活率为42.9%,3年无病存活率为14.3%.
结论:
- LRRC对CRT诱导的亡具有显著的耐药性.
- 这种细胞灭亡抵抗与手术后局部和远程复发的高率有关.
- 开发更有效的外科手术期间策略对于管理LRRC至关重要.
更多相关视频
08:55Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Published on: November 2, 2014
12.8K
04:04Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
11.0K
相关概念视频
Assessing Body Temperature - Rectal
12.1K
Rectal temperature measurement is considered the most precise method for assessing core body temperature and typically registers higher than oral temperature. For adults, the rectal thermometer should be inserted 1 to 1.5 inches into the rectum to obtain the most accurate reading.
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
Follow these steps for rectal temperature assessment:
Step 1: Perform hand hygiene and don clean gloves to prevent cross-infection.
Step 2: Position the patient in a side-lying position to better visualize the rectal...
12.1K
Local Attraction
385
Local attraction refers to disturbances in compass readings caused by magnetic influences from nearby objects such as metal fences, buried pipes, vehicles, buildings, power lines, or natural iron ore deposits. Small items like wristwatches, steel tools, or belt buckles can also interfere with the compass by creating local magnetic fields that distort the Earth's natural magnetic field. These distortions lead to inaccurate readings, posing navigation and land surveying challenges.Local...
385
Responses to Gravity and Touch
41.9K
Gravitropism: Plant Responses to Gravity
41.9K
Local Anesthetics: Pharmacokinetics
1.2K
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
1.2K
Humoral Immune Responses
83.9K
Overview
83.9K
Responses to Drought and Flooding
12.1K
Water plays a significant role in the life cycle of plants. However, insufficient or excess of water can be detrimental and pose a serious threat to plants.
12.1K
