帕拉巴克特罗伊德区分双相情感障碍与精神分裂症:对微生物生物标志物进行差异诊断
Wang Majie1,2, Hu Yifang3, Huo Yuncui1
1Department of Psychiatry, Affiliated Kangning Hospital of Ningbo University, Ningbo, Zhejiang, China.
Frontiers in microbiology
|February 2, 2026
概括
在精神分裂症和双相情感障碍中,肠道细菌有所不同. 细菌Parabacteroides可能有助于区分这些精神疾病,提供了对它们独特的生物学基础的见解.
科学领域:
- 精神病学是一个精神病学.
- 微生物学 微生物学
- 神经科学是一个神经科学.
背景情况:
- 精神分裂症 (SCZ) 和双相情感障碍 (BD) 是严重的精神疾病,其症状和生物机制重叠.
- 肠道微生物群越来越多地参与神经免疫和代谢调节,可能会影响精神疾病病理生理学.
研究的目的:
- 对SCZ,BD和健康对照 (HC) 患者的肠道微生物组成进行比较分析.
- 识别SCZ与BD区分的微生物特征,并探索它们与临床症状的关联.
主要方法:
- 从43名SCZ患者,19名BD患者和40名HC患者的便样本使用16SrRNA基因测序进行了分析.
- 评估了微生物多样性,分类构成,预测的功能途径以及与临床症状尺寸的相关性.
主要成果:
- 与HC相比,SCZ和BD患者的微生物多样性减少,肠道微生物群改变.
- SCZ表现出一种促炎特征,而BD则显示出与代谢障碍相关的功能失调.
- Parabacteroides_B_862066 丰富度将SCZ与BD区分开来 (AUC=0.87) 并与特定症状尺寸相关联.
结论:
- 甲状腺菌,特别是甲状腺菌B_862066,可以作为微生物生物标志物来区分SCZ和BD.
- 显著的微生物和功能特征表明,与微生物群相关的机制有助于精神病学异质性和亚型特定的病理生理学.
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