在Anopheles gambiae s.l.中,昆虫杀虫剂耐药性的动态. 在加纳的加纳
Christopher Mfum Owusu-Asenso1, Anisa Abdulai1, Isaac Kwame Sraku1
1Centre for Vector-Borne Disease Research, Department of Medical Microbiology, University of Ghana Medical School, Korle-Bu, Accra, Ghana.
GigaByte (Hong Kong, China)
|February 2, 2026
概括
疟疾载体Anopheles gambiae s.l. 的抗昆虫剂耐药性 是加纳的一个主要威胁. 甲状腺耐药性很高,但蚊子仍然对甲和甲敏感.
科学领域:
- 医学昆虫学 医学昆虫学
- 控制载体传播疾病 控制载体传播疾病
- 分子昆虫学分子昆虫学
背景情况:
- 在Anopheles gambiae s.l.中的抗虫剂耐药性 蚊子对撒哈拉以南非洲的疟疾控制计划构成重大威胁.
- 关键干预措施的有效性,如用杀虫剂处理的网和室内残留喷雾,由于广泛的耐药性而受到损害.
研究的目的:
- 评估Anopheles gambiae s.l.目前对杀虫剂耐药性的情况. 在加纳的人口.
- 为了识别主导的Anopheles物种和表征耐药机制.
主要方法:
- 一项从2023年至2025年在加纳20个城市和郊区进行的纵向调查.
- 世卫组织对被采样的Anopheles gambiae s.l.进行了敏感性生物测试和强度测试.
- 基因定型被用来识别特定的抗昆虫剂耐药性等位基因.
主要成果:
- 阿诺菲莱斯coluzzii (65.1%) 是主导的物种,其次是阿诺菲莱斯gambiae s.s. (18.9%) 和阿诺菲莱斯阿拉伯人 (10.9%).
- 在大多数地点观察到高甲状腺耐药性 (20-45%的死亡率).
- 观察到对皮里米-甲基和二的完全敏感性,有一些克洛西安丁的耐药性.
结论:
- 在Anopheles载体中广泛存在的铁甲状腺耐药性需要评估和部署替代杀虫剂.
- 持续监测杀虫剂耐药性对于适应加纳疟疾控制战略至关重要.
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