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在男性艾滋病毒/艾滋病患者的骨质减少风险预测和焦虑状态的多变量分析
Keke Hou1, Tao Li1, Shuyin Zhang1
1Department of Radiology, Public Health Clinical Center of Chengdu, Chengdu, China.
Frontiers in reproductive health
|February 2, 2026
概括
这项研究发现,超过一半的男性艾滋病毒/艾滋病患者经历过焦虑,并确定了导致骨质减少的关键因素. 经过验证的风险预测模型可以帮助这些患者进行早期干预.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 临床诊断 临床诊断 临床诊断
背景情况:
- 心理健康问题和骨质减少是人类免疫缺陷病毒 (HIV) /获得免疫缺陷综合征 (AIDS) 患者的重大问题.
- 公众的注意力越来越集中在艾滋病毒/艾滋病人口中的这些并发症上.
研究的目的:
- 评估男性艾滋病毒/艾滋病患者的焦虑程度.
- 在这个人群中开发和验证骨质量减少的风险预测模型.
- 确定导致骨质减少的主要因素.
主要方法:
- 一项涉及243名男性艾滋病毒/艾滋病住院患者的横截面研究,使用双能X射线吸收计 (DXA) 进行骨密度评估.
- 临床和实验室数据的追溯提取,使用汉密尔顿焦虑评分表 (HAM-A) 进行前性焦虑评估.
- 应用单变量和多变量逻辑回归,名录构造和使用AUC,C指数,Hosmer-Lemeshow测试和DCA的验证.
主要成果:
- 观察到高频率的焦虑,有55.56%的患者可能经历焦虑.
- 鉴定了六个独立的骨质减少风险因素:年龄,BMI,抗逆转录病毒疗法 (ART),特诺福维尔二硫胺 (TDF) 暴露,HBsAg阳性和抗HCV阳性.
- 开发的诺莫格拉姆模型表现出良好的预测性能,AUC为0.835和出色的校准.
结论:
- 男性艾滋病毒/艾滋病患者的骨质减少与临床因素有关,如ART持续时间,TDF暴露,年龄,BMI和病毒标记.
- 焦虑症状的高患病率需要临床关注.
- 经过验证的风险预测模型是有效的临床工具,用于识别高风险患者并促进早期干预.
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