在头部和部癌症幸存者的阻塞性睡眠呼吸暂停:系统性审查和元分析
Om Chitnis1, J Joseph Caraway2, Ngun Cer Chin1
1Division of Otolaryngology Brook Army Medical Center San Antonio Texas USA.
OTO open
|February 2, 2026
概括
头癌幸存者在治疗后有阻塞性睡眠呼吸暂停 (OSA) 的高风险. 建议对所有幸存者进行常规的OSA查,因为治疗后呼吸暂停-呼吸暂停指数增加.
科学领域:
- 在瘤学瘤学.
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 头癌 (HNC) 治疗可以显著影响患者的健康.
- 阻塞性睡眠呼吸暂停 (OSA) 是一种常见的睡眠障碍,具有严重的健康后果.
研究的目的:
- 系统地审查和元分析HNC幸存者的OSA风险.
- 为了确定HNC治疗是否会增加OSA风险,以及特定治疗是否与较高的OSA风险有关.
主要方法:
- 在主要数据库 (Embase,MEDLINE,Web of Science) 中进行全面的文献搜索.
- 包括使用HNC患者治疗前和治疗后的多睡眠学研究.
- 随机效应元分析以计算OSA患病率和呼吸暂停-呼吸暂停指数 (AHI) 变化.
主要成果:
- 包括16项与419名参与者的研究.
- 在HNC幸存者的平均OSA患病率为83.7%,从治疗前的79.9%增加到治疗后的88.7%.
- 在治疗后观察到AHI的4.28的统计显著增加.
结论:
- 在HNC幸存者中存在高OSA患病率,无论治疗方式如何.
- 建议在所有HNC幸存者中进行OSA的常规查.
- 早期发现和管理OSA可以改善HNC幸存者的结果.
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