液体活检在诊断口腔恶性瘤的潜在使用
Timbadiya Vijaykumar Mansukhbhai1, Madhvika Patidar2, Manjiri Chakor3
1Department of Oral Pathology and Microbiology, Rishiraj College of Dental Science and Research Centre, Bhopal, Madhya Pradesh, India.
Bioinformation
|February 2, 2026
概括
液体活检为早期口腔癌检测和监测提供了一种最少的侵入性方法. 分析瘤生物标志物,如ctDNA和CTCs显示承诺,但标准化和验证是临床使用的关键.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断
背景情况:
- 液体活检是口腔癌管理的一个有前途的工具.
- 它分析循环瘤DNA (ctDNA),循环瘤细胞 (CTC) 和外体.
研究的目的:
- 评估液体活检在口腔癌的早期检测和监测方面的潜力.
- 评估其在口腔状细胞癌 (OSCC) 的应用.
主要方法:
- 对ctDNA,CTC,外体和其他瘤衍生的生物标志物的分析.
- 使用最少侵入性的采样技术.
- 通过重复采样,随着时间的推移跟踪瘤负担和遗传变化.
主要成果:
- 在检测OSCC中的突变,甲基化和蛋白质标记物方面表现出良好的灵敏度和特异性.
- 允许早期检测,预后和治疗监测.
- 允许对疾病进展进行纵向跟踪.
结论:
- 液体活检是口腔癌组织活检的可行,不那么侵入性的替代方案.
- 需要进一步的标准化,生物标志物验证和成本效益研究才能得到广泛的临床采用.
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