吸烟驱动的全身炎症在高血压患者中增加死亡风险:使用NHANES 1999-2018的见解进行横截面研究
Tingting Wu1, Chufan Ren2, Chenhan Wei2
1Center for Geriatric Medicine, Key Laboratory of Alzheimer's Disease of Zhejiang Province, The First Affiliated Hospital and Institute of Aging, Wenzhou Medical University, Wenzhou, China.
Tobacco induced diseases
|February 2, 2026
概括
吸烟显著增加高血压 (HTN) 的风险和高血压患者的死亡率. 系统性炎症占这一增加的死亡率的87.70%,这凸显了戒烟和控制炎症的必要性.
科学领域:
- 心血管疾病流行病学
- 公共卫生研究 公共卫生研究
- 炎症生物标志物 炎症生物标志物
背景情况:
- 关于吸烟与高血压 (HTN) 的关联,存在相互矛盾的证据.
- 系统性炎症在高血压患者吸烟相关死亡率中的作用尚不清楚.
- 这项研究调查了吸烟,HTN风险以及系统性炎症在死亡率中的中介作用.
研究的目的:
- 为了检查吸烟状态,体积和HTN风险之间的关联.
- 确定系统性炎症 (通过SII测量) 是否调解吸烟与高血压患者全因死亡率的联系.
主要方法:
- 从NHANES (1999-2018) 中对28967名参与者的横截面分析.
- 倾向性得分匹配 (PSM) 调整为混因子.
- 使用了后勤回归,受限立方线和调解分析.
主要成果:
- 吸烟显著增加了HTN的可能性 (AOR=1.18).
- 观察到剂量与反应的关系,每天>30支香烟显示最高的HTN风险 (AOR=1.37).
- 在高血压患者中,吸烟增加了死亡率 (HR=1.993),SII占这一风险的87.70%.
结论:
- 在吸烟,HTN和死亡率之间存在显著的关联.
- 系统性炎症是高血压吸烟者死亡率增加的关键媒介.
- 针对戒烟和全身炎症的干预措施对于减少HTN相关的发病率和死亡率至关重要.
相关概念视频
Cross-Sectional Research
12.5K
In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.5K
Finding Volume Using Cross-Sectional Area
68
For solids whose cross-sectional areas vary in a predictable way, volume can be determined by integrating these areas along an axis perpendicular to the slices. This approach is particularly useful for polyhedral solids, where classical geometric formulas may not be immediately applicable. A tetrahedron provides a clear example of how cross-sectional integration can be applied to a three-dimensional object with continuously changing geometry.Consider a tetrahedron with height h and a base that...
68
Profile Leveling and Cross Sections
1.6K
Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes. Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.6K
Spinal Cord: Cross-sectional Anatomy
4.8K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.8K
Inflammation
62.1K
Overview
62.1K
Freezing Point Depression and Boiling Point Elevation
40.1K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.1K


