生物医学中的微针:创新,挑战和未来前景
Xinrui Li1, Chi Zhang1, Yuxin Zhang1
1Key Laboratory of Molecular Pharmacology and Drug Evaluation of the Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, School of Pharmacy, Yantai University, Yantai, Shandong, China.
Biomaterials translational
|February 2, 2026
概括
微针 (MN) 技术提供了先进的透皮药物输送和诊断,克服了传统方法的局限性. 这项创新有望实现个性化医疗,慢性疾病管理和改善全球健康结果.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 传统的药物输送 (口服,注射) 面临生物可用性和合规性问题,特别是对于宏分子.
- 微针 (MN) 技术为通过皮肤递送药物和诊断提供了一种新的方法.
- 在皮肤中创建MN微通道,以提供有效的治疗剂和生物标志物监测.
研究的目的:
- 审查微针分类,设计原则和各种应用.
- 突出MN在医疗保健,精准医学和全球健康方面的潜力.
- 讨论MN技术临床翻译的挑战和未来方向.
主要方法:
- 审查关于微针技术的现有文献.
- 对MN分类,制造方法和功能机制的分析.
- 探索当前和新兴的应用在药物输送,诊断和其他领域.
主要成果:
- 多核糖促进皮肤间的输送,绕过生理障碍,提高生物可用性.
- 多种网络能够实时监测慢性疾病 (如糖尿病) 的生物标志物.
- 创新包括响应刺激的MNs和与闭环系统的可穿戴设备的集成.
结论:
- 微针技术具有重大潜力,可以彻底改变药物输送,诊断和个性化医疗.
- 解决生物相容性,机械强度和药物稳定性方面的挑战对于临床翻译至关重要.
- 多重护理师为广泛的生物医学挑战提供可扩展,以患者为中心的解决方案,影响医疗保健,全球健康和食品安全.
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