胺减轻了成年雄性小鼠中甲醇酸诱导的生殖毒性
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Updated: Feb 4, 2026

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Transurethral Instillation Procedure in Adult Male Mouse
Published on: November 2, 2017
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Sally Adnan Mousa Al-Rekabi1, Rasoul Shahrooz1, Shapour Hasanzadeh1
1Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Veterinary research forum : an international quarterly journal
|February 2, 2026
概括
提氨酸 (VitB1) 补充剂可改善化学疗法引起的精子特征损伤和暴露于甲醇 (MTX) 的小鼠体外受精潜力. 这突出了胺.
科学领域:
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
- 营养科学 营养科学
背景情况:
- 化学疗法药物,如甲醇 (MTX) 引起显著的副作用,包括受损的精子质量和降低的生育能力.
- 氧化应激是导致MTX诱导的生殖毒性的关键机制.
研究的目的:
- 对雄性小鼠的精子参数和体外受精 (IVF) 能力研究胺 (维生素B1) 对甲基酸诱导的毒性的保护作用.
主要方法:
- 成年雄性小鼠被分为对照组,暴露于MTX (虚假),接受胺治疗和结合胺-MTX组.
- 在治疗后评估了精子数量,运动性,活力,DNA完整性和试管婴儿潜力.
- 与MTX一起,不同剂量的胺 (25,50,100毫克/公斤) 被给予.
主要成果:
- 甲托雷克萨特暴露显著降低了精子数量,运动性和活力,同时增加了精子DNA损伤和不成熟度.
- 与仅服用MTX的组相比,胺治疗,特别是50和100毫克/公斤,显著改善了精子数量,运动性和活力.
- 胺补充剂还提高了MTX暴露的小鼠的体外受精率和胚胎发育,表明氧化应激减少.
结论:
- 胺有效地改善了甲状腺素对雄性小鼠生殖参数和生育能力的不良影响.
- 胺的保护机制涉及缓解由MTX引起的氧化应激.
- 维生素B1显示出作为治疗辅助的潜力,以减少化疗相关的生殖毒性.
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