与代谢功能障碍相关的心血管风险分层的与风险相关的和临床信息的生物标志物 - 相关的脂肪性肝病
Jiaxin Zhong1, Yiwei Zhao1, Huifen He1
1National Clinical Research Center for Endocrine and Metabolic Diseases, Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, No. 139 Renmin Middle Road, Changsha 410011, Hunan, China.
American journal of preventive cardiology
|February 2, 2026
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 将心血管事件的风险增加一倍. 像FIB-4和FLI这样的简单标志物可以帮助在临床实践中评估和管理这种风险.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 与动脉样硬化心血管疾病 (ASCVD) 有关.
- 准确的心血管风险大小和MASLD中可用的标记物的实用性需要进一步澄清.
研究的目的:
- 评估与MASLD及其各种标签相关的心血管风险.
- 评估MASLD患者随时可用的风险标志物的临床实用性.
主要方法:
- 观察性研究和RCT (基线数据) 的系统审查和元分析.
- 搜索了PubMed,Embase,科学网络和科克兰图书馆 (2000-2025年).
- 对于10年ASCVD高风险分类和事件MACE的相对影响;评估异质性和偏差.
主要成果:
- MASLD与心血管负担增加两倍相关 (相对相对效应2.02).
- 协会在NAFLD和NASH标签上是一致的.
- 像FIB-4,FLI,血压和TyG指数这样的生物标志物有效地完善了心血管风险分层.
结论:
- MASLD显著增加了心血管事件的风险,根据背景而有所不同.
- 包括FIB-4,FLI,血压和TyG指数在内的小组可以补充ASCVD风险评估,用于早期预防.
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