转移素受体1是需要CD4+T细胞铁依赖反应在急性毒素菌感染期间
bioRxiv : the preprint server for biology
|February 2, 2026
概括
在Toxoplasma gondii感染期间的铁限制矛盾地增加了寄生虫负担,并降低了小鼠的生存率. T细胞的反应和疫苗的有效性受损,突出显示铁的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
- 传染性疾病 传染性疾病
背景情况:
- 元素铁对生物过程至关重要,包括感染和免疫力.
- 铁对 *Toxoplasma gondii* (*T. gondii*) 感染和宿主免疫力 *in vivo* 的确切影响仍然基本未知.
- 了解铁的作用对于开发有效的治疗和疫苗接种策略对*T. gondii*至关重要.
研究的目的:
- 研究铁的可用性如何影响T. gondii*感染的进展和宿主免疫反应 *in vivo*.
- 为了确定铁限制对T细胞激活,功能和疫苗诱导的免疫力对*T. gondii*的影响.
主要方法:
- 在不同的铁条件下 (限制与正常) 感染了T. gondii的小鼠.
- 分析了免疫细胞群 (T细胞,NK细胞,髓质细胞) 和细胞因子水平 (IL-12,IFN-γ).
- 使用流细胞计和二次挑战模型评估了T细胞激活,效应器功能和疫苗疗效.
- 研究了患有CD4+T细胞特异性转移素受体1 (CD71) 缺乏症的小鼠,以评估铁吸收的作用.
主要成果:
- 铁限制 * in vivo * 矛盾地增加了 * T. gondii * 寄生虫负担,并降低了小鼠的生存率.
- 铁含量低会影响CD4+和CD8+T细胞的反应,减少T细胞群和疫苗的有效性.
- T细胞对转移素受体1 (CD71) 进行上调,以吸收铁;CD4+ T细胞中的CD71缺乏减少了它们的激活和多功能性.
结论:
- 细胞对铁的获取对于它们的激活和建立长期的保护性免疫力来说是必不可少的 *T. gondii*.
- 铁的调节显著影响多个免疫区,影响对T. gondii*感染的整体免疫反应.
- 准铁代谢可能是一个新的治疗或辅助策略,用于提高免疫力和疫苗对T. gondii的有效性.
相关概念视频
The Early Endosome: Endocytosis of Transferrin
4.8K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
4.8K
Internal Receptors
74.7K
Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Requirements for Human Life
13.5K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
13.5K
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
622
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
622
Types of Receptors: Cell Surface Receptors
27.4K
Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
27.4K
Energy-requiring Steps of Glycolysis
171.6K
Glucose is the source of nearly all energy used by organisms. The first step of converting glucose into usable energy is called glycolysis. Glycolysis occurs in the cytosol of the cell over two phases: an energy-requiring phase and an energy-releasing phase. Over the first three steps, glucose is converted into different forms and attached to two phosphate groups donated by two ATP molecules, resulting in an unstable sugar. In the next two stages, the unstable sugar splits into two sugar...
171.6K


