创伤后应激障碍水平与血清炎症因子之间的关联在接受指甲移植的患者中
1Department of Emergency, People's Hospital of Rizhao, Jining Medical University, Rizhao, Shandong, China.
Frontiers in neuroscience
|February 2, 2026
概括
手术后创伤后应激障碍 (PTSD) 在数字移植后很常见,并且与炎症因素有关. 女性性别,低学历,创伤严重程度和焦虑/抑郁症影响PTSD风险,炎症标志物显示具有预测价值.
科学领域:
- 整形外科手术 整形外科手术
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 数字移植旨在恢复功能,但可能导致心理痛苦.
- 早期创伤后应激障碍 (PTSD) 是主要重建性手术后的一个重大问题.
- 了解这些人群中PTSD的生物学相关性对于及时干预至关重要.
研究的目的:
- 调查手指移植患者早期术后创伤后应激障碍的患病率.
- 检查PTSD水平与血清炎症因子之间的关联.
- 为了确定影响数字移植后PTSD发展的因素.
主要方法:
- 经过指部移植的96名患者在术后7天使用PTSD检查清单-民用版本 (PCL-C) 对PTSD进行了评估.
- 使用ELISA测量了关键炎症性细胞因子 (IFN-γ,TNF-α,IL-1β,IL-6,IL-10) 的血清水平.
- 统计分析包括单变量,相关性,多重线性回归和ROC曲线分析.
主要成果:
- 45.83%的患者表现出PTSD症状 (PCL-C平均得分为38.21±9.31).
- 创伤后应激障碍得分与焦虑和抑郁有积极的相关性,受性别,教育,受伤严重程度和重新植入的数字数量的影响.
- PCL-C评分与促炎性细胞因子 (IFN-γ,TNF-α,IL-1β,IL-6) 和抗炎性IL-10显著相关.
结论:
- 显著比例的患者在手指移植后发展早期的PTSD.
- 创伤后应激障碍与人口因素,创伤严重程度,心理并发症和炎症失衡有关.
- 血清炎症因子显示出这些患者早期PTSD风险识别的潜在生物标志物.
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