大脑对著名人脸部识别的反应作为轻度认知障碍的潜在功能生物标志物
Michihiko Koeda1,2, Yumiko Ikeda3, Yoshiro Okubo2
1Department of Neuropsychiatry, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan.
Frontiers in neuroscience
|February 2, 2026
概括
轻度认知障碍 (MCI) 患者识别面部的困难与大脑网络的早期变化有关. 副海马回环 (PHG) 和后带皮质 (PCC) 的活化减少可能会先于行为症状.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 社会认知障碍,包括面部识别困难,是轻度认知障碍 (MCI) 的早期迹象.
- 这些障碍可能导致社会退缩,动机下降和抑郁.
- 在MCI中面部识别缺陷的神经支尚未完全理解.
研究的目的:
- 研究患有MCI的个体中,近海马回形 (PHG) 和后带带皮层 (PCC) 的早期变化.
- 通过基于任务的功能磁共振成像 (fMRI) 检查面部识别的神经基础.
- 评估默认模式网络 (DMN) 在MCI社会认知缺陷中的作用.
主要方法:
- 32名参与者 (20名健康对照,12名MCI) 接受了fMRI扫描.
- 参与者完成了涉及著名面孔判断和面孔与对象分类的任务.
- 分析侧重于组和任务效应,对PHG和PCC进行了小体积校正.
主要成果:
- 健康对照组和MCI组之间的行为准确性相似.
- 在面部处理过程中,MCI参与者显示左PHG和PCC的激活显著减少.
- 左PHG激活减少在校正后仍然显著,而PCC减少不那么明显.
结论:
- 在MCI中存在PHG-PCC网络的早期变化,可能是行为衰退的先兆.
- 减少左PHG激活可能表明语义访问和内部处理的早期中断.
- 将这些神经发现与生物标志物数据相结合,可以提高对痴呆风险认知脆弱性的理解.
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