SGLT2i对慢性病患者进展的影响:中国的多中心真实世界研究
Wen-Cong Guo1, Li-Cong Su2, Bin Wang1
1Institute of Nephrology, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing, China.
Kidney diseases (Basel, Switzerland)
|February 2, 2026
概括
在中国患者中,-葡萄糖共传输体-2 抑制剂 (SGLT2i) 显著降低了慢性病 (CKD) 的进展和末期病 (ESKD). 此外,SGLT2i对心血管有好处,可在三年内保持估计的淋巴细胞过率 (eGFR).
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 现实世界的证据研究研究.
背景情况:
- 随机对照试验证实了SGLT2抑制剂在CKD中对的益处.
- 在中国CKD人群中使用SGLT2抑制剂的现实数据有限.
研究的目的:
- 评估SGLT2抑制剂在住院的中国CKD患者中的实际有效性和安全性.
- 评估SGLT2抑制剂对,安全性和临床结果的影响.
主要方法:
- 从2002年1月到2023年1月,使用中国脏数据系统 (CRDS) 进行了回顾性队列研究.
- 倾向性得分匹配 (1:2比) 用于比较1477名SGLT2抑制剂使用者与2674名非使用者.
- 结果包括CKD进展,ESKD,复合事件,安全事件和3年的eGFR变化.
主要成果:
- 使用SGLT2抑制剂与CKD进展率 (HR 0.81),ESKD (HR 0.26) 和复合结局 (HR 0.68) 的显著降低相关.
- SGLT2抑制剂降低了心力衰竭,中风和严重低血糖的风险,但增加了急性胰腺炎的风险.
- 在使用SGLT2抑制剂的3年内,估计的淋巴球过率 (eGFR) 在使用SGLT2抑制剂的患者中保持得更好.
结论:
- 在中国的CKD患者中,SGLT2抑制剂为脏和心血管提供了显著的益处.
- 现实数据支持在中国使用SGLT2抑制剂治疗CKD.
- 进一步的研究可能会探讨不同中国CKD亚组的长期安全性和有效性.
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