静脉血栓栓塞和20年癌症风险:一项基于丹麦人口的队列研究
Søren K Martiny1, Vincent Lanting2,3, Dóra K Farkas1
1Department of Clinical Epidemiology, Center for Population Medicine, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
Research and practice in thrombosis and haemostasis
|February 2, 2026
概括
静脉血栓栓塞 (VTE) 患者面临高达20年的癌症风险增加. 这种高风险,特别是与生活方式因素相关的癌症,表明共同的潜在原因.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 静脉血栓栓塞 (VTE) 与短期癌症风险有关,但长期关联和潜在机制尚不清楚.
- 了解VTE后的长期癌症风险对于患者管理和癌症预防策略至关重要.
研究的目的:
- 确定诊断为第一次VTE的患者的长期癌症风险.
- 调查癌症风险增加是否与与VTE共享风险因素的特定癌症类型有关.
主要方法:
- 丹麦 (1996-2022) 进行了一项全国性队列研究,对138,049名首次出现VTE的患者进行了跟踪.
- 癌症发病率使用累积发病率和标准化发病率比率 (SIRs) 进行分析,将观察到的与预期的发病率进行比较.
- 针对整体癌症,局部特定癌症和病因组 (吸烟,肥胖,酒精等) 进行了具体分析. ) 的情况.
主要成果:
- 一年癌症风险 (SIR) 显著上升至3.45,在长达20年的时间里保持在1.00以上.
- 在第一年内,在各种癌症群体中观察到SIRs升高,并持续长期.
- 增加的风险主要是由与吸烟,肥胖和酒精相关的癌症 (例如肺,肝脏,结肠) 和血液癌症驱动的.
结论:
- 患有VTE的患者患癌症的风险增加,诊断后长达20年.
- 共同的风险因素,包括生活方式 (吸烟,肥胖,酒精) 和潜在的遗传倾向,可能有助于观察到的关联.
- 这些发现强调了考虑VTE患者的癌症风险和调查共享的病因路径的重要性.
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