在白色脂肪储存中绘制葡萄糖诱导的血液动力学图,使用无标签的光声学
Nikolina-Alexia Fasoula1,2, Nikoletta Katsouli1,2, Michael Kallmayer3,4
1Chair of Biological Imaging, Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health, Technical University of Munich, Munich, Germany.
Photoacoustics
|February 2, 2026
概括
多谱光声学断层扫描 (MSOT) 非侵入性成像皮下脂肪组织 (SAT) 血液动力学. 较高的BMI个体在SAT中显示葡萄糖诱导的血流反应减少,表明心脏代谢健康受损.
科学领域:
- 生物医学光学 生物医学光学
- 心血管生理学心血管生理学
- 代谢健康成像 代谢健康成像
背景情况:
- 皮下脂肪组织 (SAT) 血液动力学对于评估心脏代谢健康至关重要.
- 改变的SAT功能与代谢障碍和肥胖有关.
- 需要使用非侵入性方法在体内评估SAT血液动力学.
研究的目的:
- 引入多谱光声学断层扫描 (MSOT) 作为成像人类SAT血液动力学的非侵入性工具.
- 为了研究身体质量指数 (BMI) 对不同SAT储存中的葡萄糖诱导的血液动力学反应的影响.
- 为了比较腹部和股骨SAT之间的血液动力学活动.
主要方法:
- 利用MSOT对具有低 (<24 kg/m2) 和高 (≥24 kg/m2) BMI的个体的SAT血液动力学图像.
- 服用口服葡萄糖的挑战,以评估食后血动力学变化.
- 与纵向血液标记物 (甘油三,葡萄糖,乳酸,胆固醇) 相比,验证的MSOT发现.
主要成果:
- 体重指数较高的个体在餐后60分钟的SAT中表现出显著减弱的葡萄糖诱导的高血压反应.
- 在基线时,腹部SAT表现出比部SAT更活跃的血液动力状态.
- MSOT结果与血液测试参数相关,证实了血液动力学变化.
结论:
- MSOT是一种可行的非侵入性技术,用于同时评估多个仓库的SAT血液动力学.
- 对葡萄糖挑战的SAT血液动力学反应受损与更高的BMI有关.
- MSOT提供了有关BMI和心脏代谢健康的SAT生理学的宝贵见解.
相关概念视频
Glucose Homeostasis: Regulation of Blood Glucose
4.1K
Carbohydrates consumed through foods are converted into glucose, a crucial energy source for the body. In the prandial state, high blood glucose levels stimulate the secretion of insulin from the pancreas. Insulin inhibits hepatic glucose production and stimulates glucose uptake and metabolism by muscle and adipose tissue. The excess glucose is converted into glycogen and stored in the liver and muscles.
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
4.1K
Glucose Transporters
27.5K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
27.5K
Glucose Absorption Into the Small Intestine
35.8K
Complex carbohydrates consumed cannot be absorbed into the small intestine in their original form. First, they must be hydrolyzed to a monosaccharide form such as glucose or galactose. These monosaccharides are then transported across the intestinal membrane and into the blood via transcellular transport. The intestinal epithelial cells allow the movement of these monosaccharides with a defined 'entry' through membrane transporter proteins present on their apical membrane and...
35.8K
Hormones Regulating Blood Glucose
6.8K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
6.8K
Fats as Energy Storage Molecules
27.0K
Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis...
27.0K
Microtubule Associated Proteins (MAPs)
5.9K
Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
5.9K


