在poly (I:C) -TLR3刺激下,用9-甲基丁-6-one预处理的RAW264.7小鼠巨细胞的转录组数据集
Trang Thu Tran1,2, Huyen Minh Thi Ta2, Duc Hoang Le1,2
1Institute of Biology (IB), Vietnam Academy of Science and Technology (VAST), Hanoi, 100000, Vietnam.
Data in brief
|February 2, 2026
概括
这项研究揭示了9 - methoxycanthin-6-one如何影响巨细胞在病毒免疫反应期间的基因表达. 这些数据提供了对自然化合物调节抗病毒信号通路的见解.
科学领域:
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
- 基因组学就是基因组学.
背景情况:
- 鼠类巨细胞是关键的免疫细胞.
- 9-甲西康丁-6-one是一种来自Eurycoma longifolia的化物.
- 聚氨酸 (poly) 激活了托尔类受体3 (TLR3) 的抗病毒信号传输.
研究的目的:
- 提出用9-甲基康-6-one和多I:C处理的巨细胞的RNA测序数据.
- 在病毒模拟刺激下,对这种天然类化合物反应的基因表达变化进行分析.
- 为了解巨细胞的转录基因反应提供资源.
主要方法:
- RAW264.7细胞经过9 - 甲基康-6-one的预处理,并使用聚I:C进行刺激.
- 总RNA被提取并使用Illumina平台进行测序 (对结读).
- 进行了差异基因表达分析和功能注释.
主要成果:
- 该数据集包括规范表达矩阵和差异表达基因列表.
- 途径丰富分析确定了响应基因和途径.
- 转录基因样本显示,在TLR3激活过程中,细胞对9-甲基丁-6-one的反应.
结论:
- 该数据集可以作为巨细胞对天然类化合物的转录基因反应的参考.
- 它有助于通过TLR3通路对宿主抗病毒转录反应进行比较.
- 数据可用于评估巨细胞激活,并与其他E. longifolia*化合物集成.
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