口服补充牛乳腺提取物可降低老年小鼠神经元刺激能力
Abdeslem El-Idrissi1,2, Natalia Surzenko3, Bassem F El-Khodor3
1Department of Biology and Center for Developmental Neuroscience, College of Staten Island The City University of New York New York New York USA.
FASEB bioAdvances
|February 2, 2026
概括
胸腺核分数 (TNF) 补充可能会增强老年大脑中的抑制性神经传递. 这种牛胸腺提取物降低了神经元刺激性,这表明它有可能减轻与年龄有关的神经系统变化.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 神经药理学神经药理学
背景情况:
- 衰老会改变中枢神经系统 (CNS) 的GABA活性神经传递,增加神经元刺激性,并导致神经退行.
- 乳腺核分数 (TNF),一种牛乳腺提取物,已经显示出神经保护性和抗神经炎症作用.
- 以前的研究表明,TNF可以改善创伤性脑损伤 (TBI) 模型中的功能恢复.
研究的目的:
- 为了研究TNF对老化老鼠大脑中的GABAergic神经递质的影响.
- 确定TNF补充能否调节与年龄相关的神经元刺激性变化.
主要方法:
- 生物化学测试以测量GABAergic蛋白表达 (GAD65,GAD67,GABAA受体子单元).
- 使用脑电图 (EEG) 和功率光谱密度分析评估皮层神经元活动的电生理学记录.
- 年龄较大的对照小鼠与补充低剂量 (LD) 或高剂量 (HD) TNF 的小鼠之间的比较,持续了14周.
主要成果:
- 补充TNF增加了GAD65,GAD67和GABAA受体β2/β3亚单元的表达.
- 脑电图分析显示,在补充TNF的小鼠中,振幅和功率光谱密度下降.
- 观察到与剂量相关的神经元刺激能力的减弱,由降低的高频皮质振荡幅度证实.
结论:
- 补充TNF似乎通过增加GABAergic成分来增强抑制性神经传递.
- 在老年小鼠中,TNF表现出剂量依赖的降低神经元刺激能力的能力.
- 这些发现表明TNF具有减轻与年龄相关的GABAergic功能障碍和调节神经元刺激性的潜力.
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