在肠-大脑相互作用障碍的精准医学
Brian E Lacy1, Hasan Saleh2, David J Cangemi1
1Division of Gastroenterology and Hepatology, Mayo Clinic, Jacksonville, Florida.
Gastroenterology & hepatology
|February 2, 2026
概括
精准医学,即使用患者特定数据量身定制治疗,为肠-大脑相互作用 (DGBIs) 障碍提供了潜在的治疗机会. 这种方法可以改善像IBS这样的流行DGBI的诊断和治疗.
科学领域:
- 胃肠病学 胃肠病学
- 遗传学 遗传学 是一个
- 内部医学 内部医学
背景情况:
- 精准医学利用个人遗传,环境和生活方式数据来预防,诊断和治疗疾病.
- 虽然在瘤学中已经建立,但精准医学在肠-大脑相互作用 (DGBIs) 障碍中的应用仍然有限.
- DGBIs影响全球40%的人口,包括功能性消化不良和易怒肠综合征等疾病,显著影响生活质量和医疗保健系统.
研究的目的:
- 定义精准医学并将其与个性化医学区分开来.
- 探索精准医学在管理DGBIs中的潜在应用.
- 概述在DGBI中实施精准医学的战略.
主要方法:
- 文献综述定义了精准医学及其与个性化医学的对比.
- 讨论DGBIs中精准医学的当前和潜在用途.
- 对DGBIs中的精密医学进行局限性分析并提出战略框架.
主要成果:
- 精准医学利用全面的患者数据来定制医疗策略.
- 精准医学具有显著的潜力,可以改善流行DGBI的诊断和治疗.
- 目前在DGBI中的实施是最小的,需要战略开发.
结论:
- 精准医学为推进DGBI护理提供了一个有前途的途径.
- 克服局限性和制定战略实施对于实现精准医学在DGBI中的好处至关重要.
- 需要进一步的研究和临床整合,以利用精密医学改善DGBI患者的治疗结果.
相关概念视频
Intrinsically Disordered Proteins
19.5K
Intrinsically disordered proteins are a group of proteins that do not fold into specific three-dimensional structures. Their structural flexibility allows them to complement ordered proteins to perform functions that are inaccessible to rigid structures. They are more common in eukaryotes than prokaryotes and may either be exclusively intrinsically disordered or hybrid proteins, consisting of a mix of ordered and disordered regions. The absence of a rigid structure in these proteins can be...
19.5K
Uncertainty in Measurement: Accuracy and Precision
101.2K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.
101.2K
Microorganisms in Medicine and Therapeutics
1.1K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.1K
Accuracy and Precision
15.3K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. Highly accurate...
15.3K
Combination Therapies and Personalized Medicine
6.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.1K
The Precise Definition of a Limit
309
Understanding the formal definition of a limit is essential for precise mathematical analysis. This concept allows us to rigorously determine how a function behaves near a particular point without relying on ambiguous notions such as "getting close." The ε-δ definition plays a foundational role in calculus, ensuring analytical clarity and logical consistency in limit evaluation.The formal definition states that the limit of a function f(x) as x approaches a is L, written asif for...
309


