解读双边前庭病变谱:基于病因的表型,临床概况和植入候选人途径
Joan Lorente-Piera1, Raquel Manrique-Huarte1, Ángel Ramos de Miguel2,3
1Department of Otorhinolaryngology, Clínica Universidad de Navarra, Pamplona, Spain.
Frontiers in neurology
|February 2, 2026
概括
双边带病 (BVP) 呈现出基于原因的多样化表型. 前庭眼反射 (VOR) 性能预测了动,指导了个性化的前庭眼植入物选择.
科学领域:
- 神经科学是一个神经科学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 听力学 听力学是指听力学.
背景情况:
- 双边前庭病变 (BVP) 是一种慢性疾病,由于前庭功能丧失而导致失衡和动.
- 临床表现和康复与BVP病因有很大差异.
- 了解这些差异对于开发有针对性的神经刺激和植入策略至关重要.
研究的目的:
- 分析BVP的病因和功能多样性.
- 定义患者分层的临床功能概况.
- 为了指导前庭或耳前庭植入物的候选人.
主要方法:
- 一项针对119名确定的BVP (>1年) 的成年人的多中心回顾性研究.
- 听觉静脉检测包括纯色调听力测量,视频头部脉冲测试 (vHIT),静脉唤起肌原潜力 (VEMPs) 和动态姿势学 (SOT, LOS).
- 统计分析涉及克鲁斯卡尔-瓦利斯,恩-邦费罗尼和二进制物流回归.
主要成果:
- 异常病 (29.41%) 和梅尼耶尔病 (26.89%) 是常见的病因.
- 在各病因方面观察到半圆通道收益 (p < 0.001) 和VEMP幅度 (p < 0.01) 的显著差异.
- 侧面和后半圆通道中减少的VOR增益预测了振荡.
- 11.76%的患者是前置体植入物的候选人,11.76%是耳前置体植入物的候选人.
结论:
- BVP表现出不同的表型,受到病因学的影响.
- 前庭眼反射 (VOR) 性能是振荡症的主要驱动因素.
- 整合听力状态,通道-耳管功能和补偿有助于精确选择前庭或耳-前庭植入物.
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