在人类早期胚胎中延迟的第二细胞分裂与不良的发育能力和怀孕结果有关,即使第三细胞分裂按时完成
Ran Dong1,2,3,4,5,6, Qing Li1,7, Shuiying Ma1,2,3,4,5,6
1State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproductive Medicine, Institute of Women, Children and Reproductive Health, Shandong University, Jinan 250012, China.
胚胎中延迟的第二细胞分裂显著降低了胚胎囊形成率. 然而,当单个胚胎被移植时,怀孕结果仍然相似,这突显了胚胎发育动力学对成功体外受精的重要性.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精过程中受精.
背景情况:
- 早期胚胎细胞分裂的时间是评估胚胎生存能力的关键因素.
- 了解裂变时间对胚胎细胞形成和怀孕结果的影响,对于优化体外受精 (IVF) 协议至关重要.
研究的目的:
- 为了研究第二个细胞分裂 (分裂) 的时间与IVF接受患者的怀孕结果之间的关联.
- 为了确定延迟裂解是否会影响胚胎细胞形成率和随后的植入和活产率.
主要方法:
- 一个回顾性分析 16,696 胚胎从 6,571 接受试管婴儿的患者.
- 在受精后44小时和68小时,患者根据胚芽细胞计数被分为两组.
- 倾向分数匹配 (PSM) 用于控制群体之间的基线差异.
主要成果:
- 与正常分裂的胚胎相比,延迟第二次裂变的胚胎显示出明显较低的囊胚形成率 (P < 0.001).
- 从延迟切割组到正常切割组的单个胚胎移植 (3日或冷胚囊) 中,临床怀孕和活产率是可比的.
- 双重胚胎移植涉及至少一个延迟裂解胚胎导致怀孕和活产率明显降低,而不是转移两个正常裂解的胚胎.
结论:
- 延迟的第二细胞分裂与胚胎细胞的发育潜力降低有关.
- 虽然单个胚胎转移结果可能不受影响,但延迟裂解动力学可能会对双重胚胎转移场景中的妊娠成功产生负面影响.
- 胚胎发育动力学是发育能力的重要指标,并影响试管婴儿成功率.
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