血清度升高与心脏骤停患者28天全因死亡率有关
Ping Gong1, Hong Zhao2, Peijuan Li3
11Department of Emergency, Shenzhen People's Hospital (Second Clinical Medical College, Jinan University).
在心脏骤停 (CA) 后的重症监护室 (ICU) 患者的高血清度与28天死亡风险更高有关. 这一发现强调了血清度作为CA幸存者的潜在预后标志物.
科学领域:
- 关键护理医学 关键护理医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
背景情况:
- 血清度是重症患者认可的预后指标.
- 进入重症监护室 (ICU) 的心脏骤停 (CA) 患者血清度的预后值需要进一步调查.
研究的目的:
- 为了评估血清度升高和28天死亡率在经历心脏骤停 (CA) 的成年患者之间的关联.
- 为了确定血清度是否可以作为一个独立的预后标记在ICU患者的死亡率后CA.
主要方法:
- 从2008年到2019年,798名成年CA患者被录入ICU的回顾性分析,使用来自密集护理医疗信息市场 (MIMIC) -IV数据库的数据.
- 使用第一天ICU入院度的,,葡萄糖和尿素来计算血清度.
- 倾向性得分匹配 (PSM) 用于尽量减少幸存者和非幸存者群体之间的偏差,以28天全因死亡率作为主要终点.
主要成果:
- 即使在PSM后,在ICU入院的第一天血清度升高与28天死亡率增加 (62.0%对35.5%,P<0.001) 有显著的关联.
- 通过考克斯回归分析,高血清度被确定为28天死亡率的独立预测因子.
- 血清度证明了对1日,3日,7日和28日全因死亡率的预测性能,对1日死亡率具有最强的预测能力.
结论:
- 在ICU入院的第一天,血清度升高与心脏骤停患者28天死亡率较高独立相关.
- 血清度成为一个有价值和独立的预后标志物,用于预测心脏骤停后重症患者的死亡风险.
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