传统和IQOS吸烟之间的比较横截面研究,以及对脂肪酸结合蛋白4的影响
Leen Eiad Mehiar1, Manal Mohammad Abbas1, Sima Zein2
1Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19111, Jordan.
Biomedical reports
|February 2, 2026
概括
与传统香烟相比,像IQOS这样的热不燃烧 (HNB) 设备显著增加脂肪酸结合蛋白4 (FABP4) 水平,这是血管损伤的标志物. 这项研究强调了与IQOS使用相关的健康风险,即使与传统吸烟相比.
科学领域:
- 公共卫生 公共卫生
- 生物标志物 生物标志物
- 血管健康 血管健康
背景情况:
- 烟草吸烟是一个主要的全球健康问题,约旦的传统吸烟率很高.
- 热不燃烧 (HNB) 设备,如IQOS,正在成为传统香烟的新兴替代品.
- 脂肪酸结合蛋白4 (FABP4) 是早期血管和代谢损伤的关键生物标志物.
研究的目的:
- 为了比较传统吸烟与IQOS使用对FABP4水平的影响.
- 调查其他血液标记物,包括肝酶和氧化应激指标,与吸烟习惯相关.
主要方法:
- 分析了来自204名参与者的静脉血液样本:65名IQOS使用者,75名常规吸烟者和64名非吸烟者.
- 测量完整血清,氨酸转胺酶 (ALT),C反应蛋白,超氧化物转胺酶 (SOD) 和FABP4水平.
- 三组参与者的健康标志物的统计比较.
主要成果:
- 与非吸烟者和传统吸烟者相比,IQOS吸烟者显示ALT和FABP4水平显著更高.
- 与非吸烟者相比,传统吸烟者平均体积增加.
- FABP4水平与ALT以及IQOS用户的体重正相关;运动与IQOS用户的FABP4水平较低有关.
结论:
- 传统的吸烟和IQOS的使用都会对血液组成和肝功能产生负面影响.
- IQOS吸烟与FABP4水平显著增加有关,这表明炎症和组织损伤加剧.
- 这项研究是首次证明IQOS使用对FABP4水平的影响.
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