丰坦的命运在流通中的命运
Rosaria Barracano1, Claudia Montanaro2,3, Sebastien Hascoet4
1Adult Congenital Heart Disease Centre, Congenital and Familial Arrhythmias Unit, AORN Ospedale dei Colli, Monaldi Hospital, Naples 80131, Italy.
概括
患有Fontan循环的成年人数正在增加,但他们面临严重的健康问题. 本综述涵盖了Fontan并发症,风险评估以及先进的治疗方法,如导管干预和移植.
科学领域:
- 心脏病学 心脏病学
- 儿童心脏病学 儿童心脏病学
- 成年人的先天性心脏病
背景情况:
- 芬坦手术于1968年首次进行,为单心室生理学创造了息途径.
- 越来越多的成年人现在生活在Fontan循环中,大约40%的人到达成年.
- 尽管生存率有所改善,但Fontan幸存者经历了显著的长期并发症.
研究的目的:
- 审查与Fontan循环相关的常见并发症.
- 为患者分层提出临床和死亡风险评分.
- 探索干预性心脏病学和Fontan患者心脏移植的当前进展.
主要方法:
- 关于Fontan循环并发症的文献综述.
- 对风险分层现有临床数据的分析.
- 审查当前的治疗策略,包括导管干预和移植.
主要成果:
- 与Fontan相关的并发症包括心力衰竭,心律失常和末端器官功能障碍.
- 经验证的风险评分对于识别高风险Fontan患者至关重要.
- 导管干预和心脏移植正在演变的治疗选择.
结论:
- 由于潜在的并发症,成年人患有丰丹循环需要终身专业护理.
- 风险分层工具对于个性化管理和改善结果至关重要.
- 目前正在进行的研究和干预和移植方面的进展为更好的长期预后提供了希望.
相关概念视频
Fates of Pyruvate
10.8K
Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
10.8K
Coronary Circulation
7.3K
The heart, an organ critical to survival, gets nourishment not from the blood it pumps but from a separate circulation system known as coronary circulation. This is the shortest circulation in the body and is responsible for supplying the heart with the nutrients it needs to function effectively.
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
Coronary circulation begins at the base of the aorta, where two main arteries arise—the left and right coronary arteries. These arteries encircle the heart in the coronary sulcus and supply the...
7.3K
Fetal Circulation
3.0K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
3.0K
Personal Choice and Fate Attributions
176
Some individuals interpret life events as a consequence of their personal choices and actions, while others believe that outcomes are dictated by fate or destiny. This divergence in perspective has been examined in psychological and cross-cultural studies, particularly in relation to religious faith and cultural beliefs about causality.Fate and Personal ResponsibilityPeople who emphasize personal responsibility view events as direct consequences of their decisions. For instance, breaking a leg...
176
Overview of Pulmonary Circulation
3.1K
The pulmonary circulation is a vital system in our body that acts as a bridge between the respiratory and cardiovascular systems. It serves as a transport network for deoxygenated blood from the heart to the lungs and then returns oxygen-rich blood back to the heart.
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
The process begins with the right ventricle of the heart pumping deoxygenated blood into the pulmonary trunk. This large vessel extends about 5 centimeters before splitting into the left and right pulmonary arteries. These arteries...
3.1K
Overview of Systemic and Pulmonary Circulation
10.9K
The systemic and pulmonary circuits are crucial components of the circulatory system, working together to transport blood between the heart, lungs, and the rest of the body. The process begins with pulmonary circulation, where deoxygenated blood is pumped from the right ventricle to the lungs via the pulmonary trunk and arteries. Upon reaching the lungs, the blood becomes oxygenated and returns to the heart, specifically to the left atrium, via the pulmonary veins.
The oxygenated blood is sent...
The oxygenated blood is sent...
10.9K


