一个新型一维Hg的合成,拓和生物学研究 (II) 具有抗菌和抗癌潜力的协调聚合物
Shekufeh Alaei1, Khosro Mohammadi1, Payam Hayati2
1Department of Chemistry, Faculty of Nano and Bio Science and Technology, Persian Gulf University, Bushehr, 75169, Iran, pgu.ac.ir.
一种新的协调聚合物被合成和特征. 这种化合物的纳米粒子显示出有前途的抗菌和抗癌活性,与现有治疗方法相比.
科学领域:
- 材料科学 材料科学 材料科学
- 无机化学 无机化学
- 纳米技术 纳米技术
背景情况:
- 协调聚合物 (CPs) 为各种应用提供可调节的特性.
- 基于的CP值较少被探索,但具有生物活动的潜力.
研究的目的:
- 合成和描述一种新的协调聚合物.
- 研究其纳米结构形式的抗菌和抗癌特性.
主要方法:
- 通过分层和声化学方法进行合成.
- 使用X射线衍射和晶体学进行结构分析.
- 通过XRD,IR,SEM,TGA和HSA进行表征.
- 对细菌和癌症细胞系进行生物评估.
主要成果:
- 一种新的1D协调聚合物[μ2-Cl]{Ina) {Hg}{μ3-Cl}{Hg}{μ2-Cl}{2}{Ina) ]n,已成功合成.
- 纳米结构 (1') 显示出强大的抗菌活性,对抗阳性和阴性细菌.
- 纳米粒子表现出选择性抗癌活性,消除癌细胞,同时保留正常细胞.
结论:
- 合成的协调聚合物及其纳米结构具有显著的抗菌和抗癌潜力.
- 纳米结构CP显示作为治疗剂的承诺,与标准抗生素和选择性癌症治疗相当.
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