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影响癌症miRNA-mRNA相互作用的调控性QTL:机制,方法和临床影响

Vivek Kumar¹, Rohit Shukla¹, Amit Chaudhary²

¹USF Center for Microbiome Research, Microbiomes Institute, University of South Florida, Tampa, FL, United States.

Frontiers in molecular biosciences

|February 2, 2026

概括

影响微RNA (miRNA) 相互作用的单核酸多态 (SNP),称为调控定量特征位置 (regQTLs),是癌症发展和治疗反应的关键. 了解这些规律为精确瘤学和向治疗提供了新的途径.

科学领域:

基因组学和分子生物学
癌症研究癌症研究
生物信息学是一种生物信息学.

背景情况:

微RNAs (miRNAs) 是关键的转录后调节者,影响癌症的发病,进展和治疗反应.
影响miRNA-mRNA相互作用的单核酸多态 (SNP),称为调控定量特征位点 (regQTLs),显著调节瘤基因表达.
这些regQTLs可以改变miRNA结合,转录稳定性和瘤性途径,影响癌症易感性和患者的结果.

研究的目的:

为癌症中regQTLs的生物学,计算和转化方面提供全面的审查.
总结目前研究生殖系对miRNA介导基因调节的影响的方法.
突出regQTLs作为精密瘤学的生物标志物和治疗点的潜力.

主要方法:

计算方法的审查,包括基于相互作用的regQTL模型,miR和isomiR-eQTL分析,以及基于序列的预测.
讨论 miRNA-TWAS 方法用于识别基因调节的 miRNA.
关于regQTL发现的公开可用的数据集和注释平台的摘要.

主要成果:

确定regQTLs作为瘤中基因表达的显著调节者.
突出regQTLs作为潜在的生物标志物用于预后和治疗反应在乳腺癌,肺癌,前列腺癌和结直肠癌.
探索针对miRNA-SNP相互作用的治疗策略,包括免疫疗法和mRNA疫苗.

结论:

RegQTLs代表了基因变异,miRNA调节和癌症生物学之间的关键联系.
向miRNA-SNP相互作用对开发新型癌症疗法和个性化治疗策略具有前景.
未来的研究应侧重于人群特异性分析,单细胞regQTL映射和多细胞组合,以推进精确瘤学.

关键词:

在SNP中,SNP是SNP.生物标志物生物标志物癌症癌症癌症癌症癌症我们的eQTL是eQTL.这是一个小RNARNA.监管机构的监管机构

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