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Updated: Feb 4, 2026

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通过HDAC3和YY1辅因子对RASAL1的表观遗传抑制促进纤维细胞-肌纤维细胞过渡和纤维化

Fang Chen1,2, Lijun Zhang3, Weiying Liu4

  • 1Yancheng Key Laboratory of Molecular Epigenetics, Yancheng Medical Research Center of Nanjing University Medical School, The First People's Hospital of Yancheng, Yancheng 224006, China.

Research (Washington, D.C.)
|February 2, 2026
PubMed
概括

基因组脱乙酶3 (HDAC3) 在表观遗传上抑制RASAL1,导致纤维化. 抑制HDAC3保留RASAL1,减少纤维细胞-肌纤维细胞过渡 (FMT),并缓解纤维化,提供治疗潜力.

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