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通过调节Kir2.1-依赖的巨细胞极化,TENS减轻了与CP/CPPS相关的炎症和疼痛

Ting Hong^1,2, Xinyu Liu^1,2, Zepai Chi³

¹Clinical Medical Research Center, Shantou Central Hospital, Shantou, China.

Frontiers in immunology

|February 2, 2026

概括

通过皮肤进行的电神经刺激 (TENS) 有效地治疗慢性前列腺炎/慢性骨盆疼痛综合征 (CP/CPPS). 这种疗法促进M1-to-M2巨细胞再极化,为管理这种具有挑战性的泌尿病状况提供了一种新的方法.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
免疫学免疫学免疫学
疼痛管理疼痛管理

背景情况:

慢性前列腺炎/慢性盆腔疼痛综合征 (CP/CPPS) 是一个重大的临床挑战.
巨细胞两极分化在CP/CPPS病原体中的作用需要进一步阐明.

研究的目的:

在实验性自身免疫性前列腺炎 (EAP) 中研究穿皮电神经刺激 (TENS) 的治疗效果.
探索TENS调节巨细胞极化和炎症的潜在机制.

主要方法:

在良性前列腺增生 (BPH) 组织中M1/M2巨细胞透的分析.
在老鼠中诱导EAP,并使用不同频率的TENS (1-4Hz) 进行治疗.
在RAW264.7巨细胞的体外研究中,使用电刺激 (ES) 和药理干预来研究复极化途径.

主要成果:

在BPH组织中,M1/M2巨细胞比率和炎症严重程度之间观察到正相关性.
4 Hz TENS显著降低了盆腔疼痛,降低了促炎性细胞因子水平,并改善了EAP大鼠的组织病理学.
TENS和ES诱导了M1-to-M2巨细胞再极化,与改变的离子通道表达,膜潜力,流入和信号通路有关.

结论:

通过促进M1-到M2巨细胞再极化,TENS证明了CP/CPPS的治疗潜力.
这项研究确定了TENS在治疗慢性前列腺炎/慢性骨盆疼痛综合征方面的有希望的机制.

关键词:

慢性盆腔疼痛综合征慢性盆腔疼痛综合征巨细胞是什么?巨细胞是什么?通道是的通道.在前列腺炎前列腺炎.通过皮肤进行电动神经刺激.

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