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Updated: Feb 4, 2026

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在非人类灵长类动物中利用mRNA来表达单克隆IgG和IgA

Romy Rouzeau1, Hayden R Schmidt1, Cailin E Deal2

  • 1IAVI Neutralizing Antibody Center, San Diego, CA, United States.

Frontiers in immunology
|February 2, 2026
PubMed
概括

使者RNA (mRNA) 脂质纳米粒子 (LNPs) 成功使非人类灵长类动物的治疗单克隆抗体 (mAbs) 在现场表达. 这种新的方法允许生产非IgG同型,如IgA,具有本地类似的糖化和保留治疗功能.

关键词:
人类免疫缺陷病毒 (HIV)作为信使的核糖核酸脂质纳米粒子 (mRNA-LNP).一个单克隆抗体 (mAb)非人类灵长类动物 (NHP)药物动力学 (PK) 是指

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