胃癌中ferroptosis的全球研究格局:基于多个数据库 (2017-2025) 的多学科文献计量分析 (2017-2025)
Nianshan Ji1, Yiyao Cheng1, Yuheng Peng1
1The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
Frontiers in immunology
|February 2, 2026
概括
铁,一种依赖于铁的细胞死亡,在胃癌 (GC) 研究中至关重要. 这项研究分析了全球趋势,揭示了诸如免疫检查点和STAT3-ferroptosis轴等新疗法的关键主题.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞死亡研究 细胞死亡研究
背景情况:
- 铁,一种依赖于铁的调节细胞死亡,在瘤进展和免疫调节中起着至关重要的作用.
- 胃癌 (GC) 由于其高发病率和死亡率而构成重大全球健康挑战.
研究的目的:
- 从2017年到2025年,系统地分析全球研究格局,热点和胃癌 (GC) 铁亡的趋势.
- 在GC研究中专注于ferroptosis的免疫学影响.
主要方法:
- 来自Web of Science核心集合和Scopus (2017-2025) 的974个出版物的图书统计和可视化分析.
- 使用R软件 (bibliometrix),VOSviewer和CiteSpace来检查出版趋势,合作,关键字的共同出现和主题演变.
主要成果:
- 研究产出的持续上升趋势,其中中国的出版物处于领先地位.
- 关键的研究主题包括免疫检查点,瘤免疫微环境,铁灭机制,耐药性和非编码RNA.
- STAT3-ferroptosis轴和免疫通路成为关键的翻译目标.
结论:
- 铁亡是胃癌的重要研究前沿,提供了一个有前途的治疗策略.
- 通过ferroptosis调节瘤免疫微环境可以提高免疫治疗的疗效.
- 这项研究为未来的癌症免疫学和基于铁亡的疗法研究提供了全面的概述.
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