抗抑郁药的使用和远距离半径开放缩减和内部固定后重新手术的风险:一种倾向性得分匹配的队列研究
Firdavs Kurbanov1, Christopher Dussik2, Amy Phan2
1University of Rochester School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY.
Journal of hand surgery global online
|February 2, 2026
概括
服用抗抑郁药物,包括选择性血清素再吸收抑制剂 (SSRI) 和其他血清激素药物,与远半径骨折固定后重新手术的风险增加有关. 这一发现表明,这可能会对骨折愈合和手术结果产生影响.
科学领域:
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
- 骨愈合 骨愈合 的方法
背景情况:
- 抗抑郁药的使用很普遍,可能会影响骨重塑.
- 抗抑郁药对手术修复后骨折愈合的影响尚不清楚.
研究的目的:
- 为了调查选择性血清素再吸收抑制剂 (SSRI) 和非SSRI血清素抗抑郁药和远半径骨折的开放缩小和内部固定 (ORIF) 后未计划返回手术室 (RTOR) 之间的关联.
主要方法:
- 追溯性,倾向性得分匹配的队列研究,使用TrinetX无标识电子健康记录数据.
- 对比SSRI使用者和非SSRI血清激素使用者与非使用者进行计划外RTOR在ORIF后30-365天内.
- 分析了风险差异,风险比率和危险比率.
主要成果:
- 与非使用者相比,SSRI使用与非计划性RTOR (1.8%对0.8%) 的更高率有关.
- 非SSRI类血清抗抑郁药的使用也显示,与非使用者相比,意外RTOR的风险增加 (2.4%与0.6%相比).
- 在绝对风险和事件发生时间分析中,研究结果一致.
结论:
- 术前接触SSRI或非SSRI血清激素药物与远距离半径ORIF后未计划的重新手术的小但临床显著增加有关.
- 这表明这些抗抑郁药对骨折愈合或手术部位并发症的潜在负面影响.
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