一个移动系统,用于全眼 perfusion 支持视网膜功能和手术.
Maxwell Lohss1,2, Katelin S Samski1, Alkiviades Liasis1
1Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, United States.
Frontiers in bioengineering and biotechnology
|February 2, 2026
概括
进步的直接对人眼研究 (ASTHER) 系统将整个眼睛注入血液,维持视网膜功能和血液供应. 该平台通过克服样本降解挑战,为人类组织研究带来了前景.
科学领域:
- 眼科医生 眼科 眼科
- 翻译研究是翻译研究.
- 生物医学工程 生物医学工程
背景情况:
- 人体捐赠组织对药物开发有价值,但在死亡后迅速降解,限制了其使用.
- 在死后组织中保持解剖学上下文和细胞功能是研究中的一个重大挑战.
研究的目的:
- 引入先进的直接对人眼研究 (ASTHER) 系统,这是一个新的ex vivo眼睛 perfusion平台.
- 评估使用ASTHER系统维持全眼活力和功能使用自身血液的可行性.
主要方法:
- ASTHER系统的设计是为了便携性和与外科手术技术的兼容性.
- 可行性试验涉及眼动脉通道,动脉 perfusion,视网膜成像和电视网膜学.
- 该系统在尤卡坦小猪眼睛上进行了测试,随后在使用捐赠的人类眼组织的试点研究中进行了测试.
主要成果:
- ASTHER平台成功地维持了视网膜血液供应和神经元功能在ex vivo迷你猪眼中,通过成像和电视网膜学证实了这一点.
- 视网膜手术成功地在透的眼睛上进行.
- 一项试点研究证明了该协议对捐赠的人类眼组织的适用性.
结论:
- 阿斯特系统有效地支持眼睛的活力,保持视网膜的血液供应和功能.
- 这种输液平台为转化研究中死后组织降解的局限性提供了潜在的解决方案.
- 计划进行进一步的验证研究,以量化 perfused 人眼组织的结构和功能完整性.
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