在患有pterygium的患者中,眼表面微生物群的改变
Yiyuan Guo1, Gege Tian1, Guangzhong Feng1
1Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Frontiers in cellular and infection microbiology
|February 2, 2026
概括
病患者表现出改变的眼睛表面细菌,与长时间使用电子设备相关的机会性病原体增加. 长时间的屏幕时间可能是pterygium发展的危险因素.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 基因组学就是基因组学.
背景情况:
- 是常见的眼睛疾病.
- 眼睛表面微生物群在膜发育中的作用尚未完全理解.
- 在全球范围内,电子设备的使用正在增加.
研究的目的:
- 为了研究眼睛表面微生物群的变化和pterygium患者的微生物多样性.
- 评估电子设备使用时间对这些变化的影响.
主要方法:
- 包括31名患有单侧的患者.
- 16S rRNA测序是在两只眼睛的结膜囊抽样上进行的.
- 生物信息学分析用于微生物注释和多样性评估.
主要成果:
- 在pterygium和对侧眼之间,α多样性没有显著差异.
- 在 pterygium 眼睛中增加 Chao1 和 Shannon 指数,随着长时间使用电子设备.
- 在眼中 Pseudomonas 的数量增加和 Bacteroides 的数量减少.
- 使用设备>4小时/天的患者的眼中更高的Comamonas丰度.
结论:
- 的眼睛表现出机会性病原性细菌的殖民增加.
- 长时间使用电子设备和相关的蓝光暴露可能是的危险因素.
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