从脂质切换到组织修复:溶解素如何重编程巨细胞的两极分化和功能

Rebecca Buete1, Jordan Scherer1, Andreas Patsalos2

  • 1Departments of Medicine and Physiology, Pharmacology and Therapeutics and Biomedical Engineering, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital (JHACH), St. Petersburg, FL, USA.

PubMed
概括

像D系列溶解素一样,从多可萨赫萨酸 (DHA) 衍生出的专门的亲溶解媒介 (SPM) 终止炎症并帮助组织修复. 尽管在检测和稳定性方面存在挑战,但它们的治疗潜力正在针对各种疾病进行探索.

相关概念视频

Group Polarization01:01

Group Polarization

Group polarization is the strengthening of an original group attitude following the discussion of views within a group (Teger & Pruitt, 1967). That is, if a group initially favors a viewpoint, after discussion the group consensus is likely a stronger endorsement of the viewpoint. Conversely, if the group was initially opposed to a viewpoint, group discussion would likely lead to stronger opposition.
39.2K
Switching of BJT01:22

Switching of BJT

Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are...
861
Structure of Lipids03:38

Structure of Lipids

Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
98.8K
Mismatch Repair01:36

Mismatch Repair

Overview
43.7K
Molecular Shape and Polarity03:37

Molecular Shape and Polarity

Dipole Moment of a Molecule
75.7K
What are Lipids?01:38

What are Lipids?

Overview
220.2K