在健康检查人群中甲状腺结节的危险因素:横截面研究和简化预测模型的开发
Hangtian Yu1, Jingle Cao1, Jing Han1
1General Medical Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Frontiers in endocrinology
|February 2, 2026
概括
甲状腺结节很常见,患病率随着年龄的增长而增加,女性患病率更高. 年龄,女性性别和较高的BMI是甲状腺结节的关键风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 甲状腺结节 (TNs) 在成年人群中非常普遍.
- 代谢和人口因素与TNS有关.
- 了解这些关联对于公共卫生倡议至关重要.
研究的目的:
- 调查中国健康检查队列中代谢指标和TN之间的关系.
- 开发一种简化的预测模型,用于识别患有TNS风险的个体.
- 为目标查和预防策略提供信息.
主要方法:
- 对23305名接受健康检查的成年人进行横截面分析.
- 数据收集包括人口统计,生活方式和生物化学参数.
- 多变量后勤回归确定了TN的独立风险因素.
主要成果:
- 总体TN患病率为64.7%,随年龄显著增加,女性更高.
- 确定了独立的风险因素:年龄较大 (OR=1.06/年),女性性别 (OR=2.12),BMI较高 (OR=1.04/单位).
- 一个三变量预测模型 (年龄,性别,BMI) 的AUC达到0.706.
结论:
- 年龄,女性性别和更高的BMI是甲状腺结节的重要独立风险因素.
- 虽然其他代谢问题很常见,但它们不是独立的预测因素.
- 使用年龄,性别和BMI的简化模型可以帮助在大规模查期间识别高风险个体.
相关概念视频
Cross-Sectional Research
12.5K
In cross-sectional research, a researcher compares multiple segments of the population at the same time. If they were interested in people's dietary habits, the researcher might directly compare different groups of people by age. Instead of following a group of people for 20 years to see how their dietary habits changed from decade to decade, the researcher would study a group of 20-year-old individuals and compare them to a group of 30-year-old individuals and a group of 40-year-old...
12.5K
Factors Affecting the Risk of Infection
13.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
Lifestyle Factors and Health
492
Lifestyle factors play a critical role in maintaining overall health and preventing chronic diseases. Key elements, such as regular physical activity, a nutritious diet, and abstinence from smoking, can significantly enhance physical, mental, and emotional well-being while reducing the risk of several life-threatening conditions.
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
Benefits of Physical Activity
Physical activity, whether through structured exercise or casual activities like walking, biking, or dancing, is a cornerstone of a...
492
Finding Volume Using Cross-Sectional Area
68
For solids whose cross-sectional areas vary in a predictable way, volume can be determined by integrating these areas along an axis perpendicular to the slices. This approach is particularly useful for polyhedral solids, where classical geometric formulas may not be immediately applicable. A tetrahedron provides a clear example of how cross-sectional integration can be applied to a three-dimensional object with continuously changing geometry.Consider a tetrahedron with height h and a base that...
68
Profile Leveling and Cross Sections
1.6K
Profile leveling and cross-sections are surveying methods used to determine and document terrain elevations for infrastructure projects such as highways, railroads, canals, and pipelines. These methods provide data for earthwork planning and alignment of proposed routes. Profile leveling involves measuring elevations along a fixed line to create a vertical terrain profile. A surveyor sets up a leveling instrument at the benchmark (BM) and records a backsight (BS) to determine the...
1.6K
Conservation of Small Populations
17.3K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.3K


