来自藻类衍生的欧米茄-3 DHA的食补充剂在老年SAMP 8小鼠中的潜在抗衰老作用
Ming-Yu Chou1,2, I-Hung Lin3, Chia-Jung Chen3
1Wenzhou Medical University Big One Health Development Research Institute Wenzhou City Zhejiang Province China.
Food science & nutrition
|February 2, 2026
概括
藻类Omega3-DHA补充剂在老化加速小鼠中表现出显著的抗衰老作用. 它改善了认知功能,减少了衰老标志物,并延长了寿命,没有副作用.
科学领域:
- 老年学和营养科学研究
- 生物化学和分子生物学
背景情况:
- 衰老与认知能力下降和氧化应激增加有关.
- 老化加速小鼠模型 (SAM) 用于研究衰老机制.
- 欧米茄-3脂肪酸,特别是多可沙赫萨酸 (DHA),正在研究它们的健康益处.
研究的目的:
- 在老化加速小鼠 (SAM) 中评估藻类Omega3-DHA的抗衰老潜力.
- 评估含有或不含脂的DHA补充剂对衰老标志物和认知功能的影响.
主要方法:
- 雄性和雌性SAMP8小鼠在13周内服用不同剂量的藻类Omega3-DHA,含有或不含脂.
- 评估了衰老得分,认知表现 (学习和记忆),大脑衰老生物标志物 (8-OHdG,TBARS,蛋白碳,Aβ),肝脏抗氧化酶活动 (SOD,CAT,GPx) 和生存率.
- 监测身体重量和活动水平以检测有害影响.
主要成果:
- 在所有群体的雄性小鼠和补充酸丁胆 (PC) 和酸丁 (PS) 的雌性小鼠中观察到老化得分的显著减少.
- 在所有实验组中,学习和记忆的显著改善.
- 在PC和PS组中,减少了大脑衰老生物标志物 (8-OHdG,TBARS,蛋白碳酸,Aβ) 和增加了肝脏抗氧化酶活性 (SOD,CAT,GPx).
- 与对照组相比,雄性和雌性小鼠的生存时间延长,对体重或活动没有不良影响.
结论:
- 藻类Omega3-DHA补充剂有效地延迟了SAM小鼠的衰老.
- DHA增强认知功能和抗氧化防御,同时减少关键的衰老生物标志物.
- 藻类Omega3-DHA,特别是与脂一起,显示出作为抗衰老干预措施的营养策略的希望.
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