对MASLD进行监督的生活方式改善计划的经济价值和临床关联
Maurizio Polignano1, Antonella Bianco2, Davide Guido3
1Clinical Trial Unit - National Institute of Gastroenterology - I.R.C.C.S "Saverio de Bellis", Castellana Grotte, Italy.
Frontiers in pharmacology
|February 2, 2026
概括
监督的生活方式计划改善了新陈代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的生活质量和减少肝脂肪. 该干预措施证明了成本效益,支持其在常规护理中的价值.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
- 卫生经济学 卫生经济学
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种流行且可能进展的肝病.
- 虽然新药有前途,但结构化的生活方式干预仍然对MASLD管理至关重要.
- 新兴的药理选择,如resmetirom和GLP-1受体激动剂,针对特定的患者亚组.
研究的目的:
- 为MASLD患者进行多学科,动理学监督的生活方式计划的成本效益分析.
- 评估该计划对与健康相关的生活质量和临床标志物的影响.
- 从医疗保健系统的角度评估该计划的成本效益.
主要方法:
- 一项前后观察性研究分析了27名接受监督炼和饮食咨询的MASLD患者.
- 测量了与健康相关的生活质量 (SF-36至EQ-5D),肝硬化症,血压和氨基转移酶.
- 进行了成本效益分析 (ICER,QALY) 和敏感性分析,包括药品和疾病进展成本.
主要成果:
- 观察到质量调整后生命年 (QALY) 增长为0.081.
- 基础情况的增量成本效益比率 (ICER) 为17,778欧元/QALY,在标准支付意愿门下,成本效益的概率很高.
- 超声波评估的肥胖症等级,血压和AST/ALT水平有所改善,持续体力活动在2年随访时超过55%.
结论:
- 监督的生活方式计划在MASLD患者中显示出有利的成本效益结果和临床改善.
- 调查结果支持该项目的价值,将其纳入常规临床护理.
- 需要通过受控研究进一步证实.
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