益生菌优于抗氧化剂在改善男性的精液参数与异常性oligoasthenoteratozoospermia:一个随机对照试验
Farshad Gholipour1, Davoud Gharakhani2, Amirhossein Rahavian3
1Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Iranian journal of medical sciences
|February 2, 2026
概括
益生菌显著改善精子度,运动性和形态在男性与异常性oligoasthenoteratozoospermia (iOAT). 这项研究发现益生菌在IOAT治疗中比抗氧化剂更有效.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 微生物学 微生物学
背景情况:
- 异形性化化 (IOAT) 具有显著的治疗挑战.
- 目前对IOAT的治疗策略需要进一步调查和比较.
- 评估益生菌等新型治疗剂对于改善男性生育能力至关重要.
研究的目的:
- 为了比较益生菌与抗氧化剂和安慰剂在改善iOAT男性的精子参数方面的疗效.
- 评估益生菌补充剂对精子度,运动性和形态学的影响.
- 提供基于证据的洞察力,了解IOAT的新型治疗方案.
主要方法:
- 一个三重盲目的随机对照试验,涉及110名被诊断为IOAT的男性.
- 参与者被分配每天接受益生菌 (Familact®),抗氧化剂 (Sperigen®) 或安慰剂3个月.
- 用计算机辅助精液分析评估精子参数,通过线性混合效应模型评估变化.
主要成果:
- 与安慰剂相比,在益生菌组中观察到精子度,运动性和形态学的显著改善.
- 益生菌在增强精子形态和运动性方面表现出比抗氧化剂更高的疗效.
- 整个组的精液量没有显著变化.
结论:
- 与抗氧化剂相比,益生菌补充显示出优越的治疗潜力,可以改善IOAT患者的精子运动和形态.
- 这项研究提供了第一次直接比较iOAT治疗中的益生菌和抗氧化剂.
- 需要进一步的广泛研究来巩固关于iOAT管理中的益生菌疗效的结论.
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